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In this study, a novel stratagem is presented for versatile and controllable drug delivery by integrating photoresponsive drug delivery microspheres (PDDMs) into pyramid microneedle (MN) arrays. The PDDMs, containing black\u2010phosphorus (BP) and poly (<jats:italic>N<\/jats:italic>\u2010isopropylacrylamide) (pNIPAM), are generated by a flexible capillary microfluidic method. Benefiting from the high water\u00a0content\u00a0of the pNIPAM hydrogel, various bioactive substances can be loaded and maintain biological activity. Furthermore, due to the near\u2010infrared (NIR) absorption and conversion capabilities of the contained BP, the PDDMs can increase temperature, shrink volume, and release their encapsulated bioactives under the trigger of biocompatible NIR. In addition, as the PDDMs are stuffed into the solid MN arrays of porous ethoxylated trimethylolpropane triacrylate (ETPTA), the composited PDDMs\u2013MNs system has enough mechanical strength to penetrate into the skin and can deliver drugs underneath the skin uniformly. Based on the resultant PDDMs\u2013MNs, it is demonstrated that insulin can be controllably released to adjust blood glucose levels of streptozotocin (STZ)\u2010induced diabetic mice. Thus, it is believed that the PDDMs\u2013MNs can act as an excellent drugs delivery system and will find many practical values in clinical medicine.<\/jats:p>","DOI":"10.1002\/adhm.202002249","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T13:12:06Z","timestamp":1615295526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Responsive Hydrogel Microcarrier\u2010Integrated Microneedles for Versatile and Controllable Drug Delivery"],"prefix":"10.1002","volume":"10","author":[{"given":"Lu","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Institute of Translational Medicine The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing 210008 China"},{"name":"State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Institute of Translational Medicine The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing 210008 China"},{"name":"State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"},{"name":"Department of Endocrinology Zhongda Hospital School of Medicine Southeast University  Nanjing 210009 P. 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