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Three different inorganic:organic ratios of poly(methyl methacrylate\u2010<jats:italic>co<\/jats:italic>\u20103\u2010(trimethoxysilyl)propyl methacrylate)\u2010<jats:italic>star<\/jats:italic>\u2010SiO<jats:sub>2<\/jats:sub> hybrid inks are printed with pore channels in the range of 100\u2013200\u00a0\u00b5m. Mechanical properties of the 3D printed scaffolds fall within the range of trabecular bone, and MC3T3 pre\u2010osteoblast cells are able to adhere to the scaffolds in vitro, regardless of their compositions. Osteogenic and angiogenic properties of the hybrid scaffolds are shown using a rat calvarial defect model. Hybrid scaffolds with 40:60 inorganic:organic composition are able to instigate new vascularized bone formation within its pore channels and polarize macrophages toward M2 phenotype. 3D printing inorganic\u2013organic hybrids with sophisticated polymer structure opens up possibilities to produce novel bone graft materials.<\/jats:p>","DOI":"10.1002\/adhm.202100117","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T02:39:28Z","timestamp":1620268768000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["3D Printed Porous Methacrylate\/Silica Hybrid Scaffold for Bone Substitution"],"prefix":"10.1002","volume":"10","author":[{"given":"Justin J.","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Materials Imperial College London  London SW7 2AZ United Kingdom"},{"name":"Center for Biomaterials, Biomedical Research Institute Korea Institute of Science and Technology (KIST)  Seoul 02792 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yoo","sequence":"additional","affiliation":[{"name":"Center for Biomaterials, Biomedical Research Institute Korea Institute of Science and Technology (KIST)  Seoul 02792 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S. 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