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A noninvasive, wireless, and accurate alternative would greatly improve the quality of patient care. Recently introduced classes of wireless, skin\u2010interfaced devices offer capabilities in continuous, precise monitoring of physiologic waveforms and vital signs in pediatric and neonatal patients, but have not yet been employed for continuous tracking of systolic and diastolic BP\u2014critical for guiding clinical decision\u2010making in the PICU. The results presented here focus on materials and mechanics that optimize the system\u2010level properties of these devices to enhance their reliable use in this context, achieving full compatibility with the range of body sizes, skin types, and sterilization schemes typically encountered in the PICU. Systematic analysis of the data from these devices on 23 pediatric patients, yields derived, noninvasive BP values that can be quantitatively validated against direct recordings from arterial lines. The results from this diverse cohort, including those under pharmacological protocols, suggest that wireless, skin\u2010interfaced devices can, in certain circumstances of practical utility, accurately and continuously monitor BP in the PICU patient population.<\/jats:p>","DOI":"10.1002\/adhm.202100383","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T07:55:34Z","timestamp":1620028534000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Wireless, Skin\u2010Interfaced Devices for Pediatric Critical Care: Application to Continuous, Noninvasive Blood Pressure Monitoring"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4308-389X","authenticated-orcid":false,"given":"Claire","family":"Liu","sequence":"first","affiliation":[{"name":"Querrey Simpson Institute for Bioelectronics Northwestern University  Evanston IL 60208 USA"},{"name":"Department of Biomedical Engineering Northwestern University  Evanston IL 60208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Querrey Simpson Institute for Bioelectronics Northwestern University  Evanston IL 60208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Soo","family":"Kwak","sequence":"additional","affiliation":[{"name":"Querrey Simpson Institute for Bioelectronics Northwestern University  Evanston IL 60208 USA"},{"name":"School of Advanced Materials Science and Engineering Sungkyunkwan University (SKKU)  Suwon 16419 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelie","family":"Hourlier\u2010Fargette","sequence":"additional","affiliation":[{"name":"Querrey Simpson Institute for Bioelectronics Northwestern University  Evanston IL 60208 USA"},{"name":"Universit\u00e9 de Strasbourg CNRS Institut Charles Sadron  Strasbourg F\u201067000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raudel","family":"Avila","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Northwestern University  Evanston IL 60208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Vogl","sequence":"additional","affiliation":[{"name":"Division of Pediatric Autonomic Medicine Department of Pediatrics Ann &amp; Robert H. 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