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In the immune system, it can activate macrophages and represents a potential therapeutic for various diseases. To specifically deliver iron to macrophages, iron oxide nanoparticles are embedded in polymeric micelles of reactive polysarcosine<jats:italic>\u2010block\u2010<\/jats:italic>poly(<jats:italic>S<\/jats:italic>\u2010ethylsulfonyl\u2010<jats:sc>l<\/jats:sc>\u2010cysteine). Upon surface functionalization via dihydrolipoic acid, iron oxide cores act as crosslinker themselves and undergo chemoselective disulfide bond formation with the surrounding poly(<jats:italic>S<\/jats:italic>\u2010ethylsulfonyl\u2010<jats:sc>l<\/jats:sc>\u2010cysteine) block, yielding glutathione\u2010responsive core cross\u2010linked polymeric micelles (CCPMs). When applied to primary murine and human macrophages, these nanoparticles display preferential uptake, sustained intracellular iron release, and induce a strong inflammatory response. This response is also demonstrated in vivo when nanoparticles are intratracheally administered to wild\u2010type C57Bl\/6N mice. 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