{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:44:25Z","timestamp":1791225865964,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007887","name":"Harvard School of Engineering and Applied Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007887","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinically viable formulations of hydrophobic drugs, for example, chemotherapeutics, require strategies to promote sufficient drug solubilization. However, such strategies often involve the use of organic solvents that pose a significant risk in generating toxic, unstable products. Using verteporfin as a drug, a deep eutectic solvent (DES)\u2010based approach to solvate drugs in a simple one\u2010step process is reported. Lipoidal DES composed of choline and oleate is used to successfully solvate verteporfin, resulting in stable sub\u2010100\u00a0nm nanocomplexes. The nanocomplexes successfully demonstrate efficient cellular uptake as well as retention, tumor spheroid penetration, and tumor accumulation in vivo. Systemic administration of the formulation significantly inhibits the primary tumor growth and its lung metastasis in the orthotopic 4T1 murine breast tumor model. Collectively, biocompatible DES shows great potential as a novel material for intravenous formulation of chemotherapeutics.<\/jats:p>","DOI":"10.1002\/adhm.202100585","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T07:07:48Z","timestamp":1628147268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A Deep Eutectic Solvent\u2010Based Approach to Intravenous Formulation"],"prefix":"10.1002","volume":"10","author":[{"given":"Jayoung","family":"Kim","sequence":"first","affiliation":[{"name":"John A. Paulson School of Engineering and Applied Sciences Harvard University  Cambridge MA 02138 USA"},{"name":"Wyss Institute of Biologically Inspired Engineering Harvard University  Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Shi","sequence":"additional","affiliation":[{"name":"John A. Paulson School of Engineering and Applied Sciences Harvard University  Cambridge MA 02138 USA"},{"name":"Wyss Institute of Biologically Inspired Engineering Harvard University  Boston MA 02115 USA"},{"name":"Present address: Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical Sciences Peking University  Beijing 100191 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Kwon","sequence":"additional","affiliation":[{"name":"John A. Paulson School of Engineering and Applied Sciences Harvard University  Cambridge MA 02138 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Gao","sequence":"additional","affiliation":[{"name":"John A. Paulson School of Engineering and Applied Sciences Harvard University  Cambridge MA 02138 USA"},{"name":"Wyss Institute of Biologically Inspired Engineering Harvard University  Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2459-8305","authenticated-orcid":false,"given":"Samir","family":"Mitragotri","sequence":"additional","affiliation":[{"name":"John A. Paulson School of Engineering and Applied Sciences Harvard University  Cambridge MA 02138 USA"},{"name":"Wyss Institute of Biologically Inspired Engineering Harvard University  Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.005660"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-018-0005-0"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-019-03910-6"},{"key":"e_1_2_9_2_3","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11020055"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2015.07.003"},{"key":"e_1_2_9_4_1","first-page":"456","volume":"54","author":"Mottu F.","year":"2000","journal-title":"PDA J. Pharm. Sci. Technol."},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-012-9339-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.268"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.11.191"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00562"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1722338115"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.03.018"},{"key":"e_1_2_9_8_3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1403995111"},{"key":"e_1_2_9_9_1","first-page":"13","volume":"6","author":"Chowdhary R. K.","year":"2003","journal-title":"J. Pharm. Pharm. Sci."},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.557429"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.8b00640"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b00959"},{"key":"e_1_2_9_10_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.05.047"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.05.057"},{"key":"e_1_2_9_12_1","first-page":"e54040","volume":"114","author":"Paschall A. V.","year":"2016","journal-title":"J. Visualized Exp."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-019-0898-7"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.05.015"},{"key":"e_1_2_9_13_3","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13138"},{"key":"e_1_2_9_13_4","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-017-0612-3"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2019.111533"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11111760"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001455"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.04.018"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11607"},{"key":"e_1_2_9_18_1","first-page":"878","volume":"8","author":"Tannock I. F.","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"e_1_2_9_19_1","first-page":"311","volume":"162","author":"Qi Q. M.","year":"2019","journal-title":"J. Controlled Release"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abe3889"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1212021109"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9LC00135B"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202100585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202100585","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202100585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T17:37:10Z","timestamp":1759772230000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202100585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,5]]},"references-count":35,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/adhm.202100585"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202100585","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,5]]},"assertion":[{"value":"2021-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2100585"}}