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However, their relatively large sizes (ranging from tens to hundreds of nanometers) usually lead to low ROS utilization and body metabolism, thus enlarging their long\u2010term toxicity and low therapeutic effect. To solve these shortcomings, herein the ultrasmall Gd<jats:sup>3+<\/jats:sup>\u2013hemoporfin framework nanodots (GdHF\u2010NDs\uff0c \u22485 nm) is reported as efficient nano\u2010sonosensitizers. Compared with GdHF aggregation (GdHF\u2010A, \u2248400\u00a0nm), the ultrasmall GdHF\u2010NDs generate 2.3\u2010fold toxic ROS amount under similar conditions, due to shorter diffusion path and larger relative specific surface area. When the GdHF\u2010NDs dispersion is introvenously injected into tumor\u2010bearing mouse, they are accumulated within tumors to provide high magnetic resonance imaging (MRI) contrast. Under US irradiation, the GdHF\u2010NDs achieve a better sonodynamic therapeutic efficacy for tumors, compared with that from GdHF\u2010A. More importantly, owing to ultrasmall size, most of GdHF\u2010NDs can be rapidly cleared through the renal pathway. Therefore, GdHF\u2010NDs can be used as a biosafety and high\u2010performance sonodynamic agent for cancer theranostics.<\/jats:p>","DOI":"10.1002\/adhm.202100703","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T04:56:20Z","timestamp":1628312180000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Sub 5\u00a0nm Gd<sup>3+<\/sup>\u2013Hemoporfin Framework Nanodots for Augmented Sonodynamic Theranostics and Fast Renal Clearance"],"prefix":"10.1002","volume":"10","author":[{"given":"Peng","family":"Geng","sequence":"first","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuo","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Wen","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Zhang","sequence":"additional","affiliation":[{"name":"National United Engineering Laboratory for Biomedical Material Modification Branden Biomedical Park Qihe Advanced Science &amp; 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