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Shapiro et\u00a0al. conducted novel islet transplantation with a glucocorticoid\u2010free immunosuppressive agent in 2000 and achieved great success; since then, islet transplantation has been increasingly regarded as a promising strategy for the curative treatment of T1DM. However, many unavoidable challenges, such as a lack of donors, poor revascularization, blood\u2010mediated inflammatory reactions, hypoxia, and side effects caused by immunosuppression have severely hindered the widespread application of islet transplantation in clinics. Biomaterial\u2010based encapsulation and delivery strategies are proposed for overcoming these obstacles, and have demonstrated remarkable improvements in islet transplantation outcomes. Herein, the major problems faced by islet transplantation are summarized and updated biomaterial\u2010based strategies for islet transplantation, including islet encapsulation across different scales, delivery of stem cell\u2010derived beta cells, co\u2010delivery of islets with accessory cells and immunomodulatory molecules are highlighted.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202100965","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T02:15:37Z","timestamp":1630721737000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Advances in Encapsulation and Delivery Strategies for Islet Transplantation"],"prefix":"10.1002","volume":"10","author":[{"given":"Siying","family":"Wu","sequence":"first","affiliation":[{"name":"Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province School of Biomedical Engineering Sun Yat\u2010sen University  Guangzhou 510006 P. 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