{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:01:08Z","timestamp":1791298868303,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773272"],"award-info":[{"award-number":["81773272"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972886"],"award-info":[{"award-number":["81972886"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["21YF1444800"],"award-info":[{"award-number":["21YF1444800"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gastric cancer is one of the most common malignant tumors, which remains as an obstacle to human health. Nowadays, targeted nanoparticles to gastric tumor tissues, provide new strategy for improved therapy but still remain challenging. The major hurdle of targeted therapeutic nanoparticles comes from the limited enrichment and poor selectivity of therapeutic agents in in situ tumor. Herein, a pH\u2010sensitive targeted nano platform coloaded As<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> and human epidermal growth factor receptor\u20102 (HER2)\u2010siRNA (AH RNPs) is developed to achieve targeting therapy in orthotopic gastric carcinoma. AH RNPs can effectively prevent the degradation of siRNA and overcome the poor solubility of As<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>. In vitro studies show that AH RNPs could achieve synergistic inhibition of growth and metastasis on SGC7901 cells. Surprisingly, AH RNPs not only target gastric subcutaneous tumor, but also target in situ tumor, and express loaded genes in in situ tumor. Moreover, AH RNPs show excellent antitumor effect in orthotopic gastric tumor model and the anticancer mechanism is related about inhibiting the activation of ERK signal and downregulating the expression of cxc chemokine receptor 4 (CXCR4), HER2, MMP2, and MMP9 protein. This study provides a multi\u2010functional vector for precise targeting therapy of gastric cancer, which may serve as a potential clinical application for future gastric cancer.<\/jats:p>","DOI":"10.1002\/adhm.202100966","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T04:26:25Z","timestamp":1628310385000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Precise Targeting Therapy of Orthotopic Gastric Carcinoma by siRNA and Chemotherapeutic Drug Codelivered in pH\u2010Sensitive Nano Platform"],"prefix":"10.1002","volume":"10","author":[{"given":"Quan","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of Medicine School of Biomedical Engineering Shanghai Jiao Tong University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of Medicine School of Biomedical Engineering Shanghai Jiao Tong University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of Medicine School of Biomedical Engineering Shanghai Jiao Tong University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanrong","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of Medicine School of Biomedical Engineering Shanghai Jiao Tong University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of Medicine School of Biomedical Engineering Shanghai Jiao Tong University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of Medicine School of Biomedical Engineering Shanghai Jiao Tong University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of Medicine School of Biomedical Engineering Shanghai Jiao Tong University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of Medicine School of Biomedical Engineering Shanghai Jiao Tong University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of Medicine School of Biomedical Engineering Shanghai Jiao Tong University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjiang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Harbin Medical University Cancer Hospital Harbin Medical University  Harbin Heilongjiang 150081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Implantology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine National Clinical Research Center for Oral Diseases  Shanghai 200001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3781-7845","authenticated-orcid":false,"given":"Yourong","family":"Duan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of Medicine School of Biomedical Engineering Shanghai Jiao Tong University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,7]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70546-1"},{"key":"e_1_2_8_1_2","first-page":"251","volume":"3","author":"Hu B.","year":"2012","journal-title":"J. Gastrointest. Oncol."},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2017.01.006"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2017.1315406"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3030"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316039"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.14"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202100130"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201202296"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b00027"},{"key":"e_1_2_8_5_4","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201903296"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119840"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b00083"},{"key":"e_1_2_8_6_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2019.02.007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr800427g"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2011.07.010"},{"key":"e_1_2_8_7_3","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201300083"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202002922"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c00852"},{"key":"e_1_2_8_8_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b12140"},{"key":"e_1_2_8_8_4","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201706124"},{"key":"e_1_2_8_8_5","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2017.2429"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn169"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.09.027"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.08.050"},{"key":"e_1_2_8_11_1","first-page":"44","volume":"8","author":"Alimoghaddam K.","year":"2014","journal-title":"Int. J. Hematol. \u2010 Oncol. Stem Cell Res."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2839-3"},{"key":"e_1_2_8_12_2","first-page":"2190","volume":"8","author":"Jiang L.","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"e_1_2_8_12_3","first-page":"1133","volume":"8","author":"Chang K.\u2010J.","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-1947"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2018.03.062"},{"key":"e_1_2_8_14_2","first-page":"4185","volume":"7","author":"Wang R.","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6428"},{"key":"e_1_2_8_16_1","first-page":"4127","volume":"34","author":"Jang S. Y.","year":"2014","journal-title":"Anticancer Res."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1196-1236"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i11.1990"},{"key":"e_1_2_8_17_3","first-page":"51","volume":"58","author":"Lee C. W.","year":"2016","journal-title":"ymj"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201800229"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2015.1126769"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202100966","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202100966","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202100966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T15:39:57Z","timestamp":1759765197000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202100966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,7]]},"references-count":39,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/adhm.202100966"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202100966","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,7]]},"assertion":[{"value":"2021-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2100966"}}