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Herein, a novel approach is reported to design photothermal agents with high PCE values by promoting nonradiative heat generation processes through the cooperation of twisted intramolecular charge transfer (TICT) and molecular motions. Within the designed molecule 2DMTT\u2010BBTD, the tetraphenylethenes act as molecular rotors, the long alkyl chain grafted thiophene helps to twist the molecular geometry to facilitate TICT state formation and preserve molecular motions in aggregate, while the strong electron\u2010withdrawing BBTD unit enhances TICT effect. 2DMTT\u2010BBTD exhibits NIR\u2010absorption and a high PCE value of 74.8% under 808\u00a0nm laser irradiation. Gambogic acid (GA) which surmounts tumor cell thermotolerance by inhibiting heat shock protein 90 (HSP90) expression is coloaded into the nanoparticles, RGD peptide is further introduced to the nanoparticle surface to improve tumor accumulation. The resultant nanoparticles facilitate the effective low\u2010temperature hyperthermia therapy of muscle\u2010invasive bladder cancer (MIBC) with minimal damage to surrounding heathy tissues. This work delivers a new design concept for development of highly efficient photothermal agents, which also provides a safer approach for noninvasive treatment of MIBC and other malignant tumors.<\/jats:p>","DOI":"10.1002\/adhm.202101063","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T04:22:39Z","timestamp":1631074959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Boosting Photothermal Theranostics via TICT and Molecular Motions for Photohyperthermia Therapy of Muscle\u2010Invasive Bladder Cancer"],"prefix":"10.1002","volume":"10","author":[{"given":"Sheng","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Urology Tianjin First Central Hospital  Tianjin 300192 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heqi","family":"Gao","sequence":"additional","affiliation":[{"name":"Frontiers Science Center for Cell Responses State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials Ministry of Education and College of Life Sciences Nankai University  Tianjin 300071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology First Central Clinical College Tianjin Medical University  Tianjin 300052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqiang","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Urology First Central Clinical College Tianjin Medical University  Tianjin 300052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoliang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology First Central Clinical College Tianjin Medical University  Tianjin 300052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology Tianjin First Central Hospital  Tianjin 300192 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxue","family":"Feng","sequence":"additional","affiliation":[{"name":"AIE Institute State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates School of Materials Science and Engineering South China University of Technology  Guangzhou 510640 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1873-6510","authenticated-orcid":false,"given":"Dan","family":"Ding","sequence":"additional","affiliation":[{"name":"Frontiers Science Center for Cell Responses State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials Ministry of Education and College of Life Sciences Nankai University  Tianjin 300071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03095"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2012.02.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42765-020-00053-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42765-020-00040-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.07.033"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.09.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/BLC-160072"},{"key":"e_1_2_7_9_1","first-page":"14","volume":"10","author":"Hu W.","year":"2018","journal-title":"Nat. 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