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Various targets during the viral life\u2010cycle can be considered to inhibit viral infection, from viral attachment to viral fusion or replication. Macromolecules represent a particularly attractive class of therapeutics due to their multivalency and versatility. Although several antiviral macromolecules hold great promise in clinical applications, the emergence of resistance after prolonged exposure urges the need for improved solutions. In the present article, the recent advancement in the discovery of antiviral peptides and polymers with diverse structural features and antiviral mechanisms is reviewed. Future perspectives, such as, the development of virucidal peptides\/polymers and their coatings against SARS\u2010CoV\u20102 infection, standardization of antiviral testing protocols, and use of artificial intelligence or machine learning as a tool to accelerate the discovery of antiviral macromolecules, are discussed.<\/jats:p>","DOI":"10.1002\/adhm.202101113","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T07:48:53Z","timestamp":1633333733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Broad\u2010Spectrum Antiviral Peptides and Polymers"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6932-5239","authenticated-orcid":false,"given":"Agn\u00e8s","family":"Kuroki","sequence":"first","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore 117597 Singapore"},{"name":"Institute of Bioengineering and Bioimaging  31 Biopolis Ways, The Nanos Singapore 138669 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3802-9901","authenticated-orcid":false,"given":"Joyce","family":"Tay","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering and Bioimaging  31 Biopolis Ways, The Nanos Singapore 138669 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8652-6403","authenticated-orcid":false,"given":"Guan Huei","family":"Lee","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore 117597 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1871-5448","authenticated-orcid":false,"given":"Yi Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering and Bioimaging  31 Biopolis Ways, The Nanos Singapore 138669 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1051\/vetres\/2010010","volume":"41","author":"Domingo E.","year":"2010","journal-title":"Vet. 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