{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:23:23Z","timestamp":1788272603988,"version":"build-2803163510"},"reference-count":65,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["K08DE023552"],"award-info":[{"award-number":["K08DE023552"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE026578"],"award-info":[{"award-number":["R01DE026578"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005922","name":"International Association for Dental Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005922","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Periodontitis is a chronic inflammatory, bacteria\u2010triggered disorder affecting nearly half of American adults. Although some level of tissue regeneration is realized, its low success in complex cases demands superior strategies to amplify regenerative capacity. Herein, highly ordered scaffolds are engineered via Melt ElectroWriting (MEW), and the effects of strand spacing, as well as the presence of a nanostructured fluorinated calcium phosphate (F\/CaP) coating on the adhesion\/proliferation, and osteogenic differentiation of human\u2010derived periodontal ligament stem cells, are investigated. Upon initial cell\u2010scaffold interaction screening aimed at defining the most suitable design, MEW poly(\n                    <jats:italic>\u03b5<\/jats:italic>\n                    \u2010caprolactone) scaffolds with 500\u00a0\u00b5m strand spacing are chosen. Following an alkali treatment, scaffolds are immersed in a pre\u2010established solution to allow for coating formation. The presence of a nanostructured F\/CaP coating leads to a marked upregulation of osteogenic genes and attenuated bacterial growth. In vivo findings confirm that the F\/CaP\u2010coated scaffolds are biocompatible and lead to periodontal regeneration when implanted in a rat mandibular periodontal fenestration defect model. In aggregate, it is considered that this work can contribute to the development of personalized scaffolds capable of enabling tissue\u2010specific differentiation of progenitor cells, and thus guide simultaneous and coordinated regeneration of soft and hard periodontal tissues, while providing antimicrobial protection.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202101152","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T03:02:00Z","timestamp":1627959720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["A Highly Ordered, Nanostructured Fluorinated CaP\u2010Coated Melt Electrowritten Scaffold for Periodontal Tissue Regeneration"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8328-1818","authenticated-orcid":false,"given":"Arwa","family":"Daghrery","sequence":"first","affiliation":[{"name":"Department of Cariology Restorative 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 Alexandria VA 22314 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9241-7676","authenticated-orcid":false,"given":"Jos","family":"Malda","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Center University Medical Center Utrecht  Utrecht 3508 The Netherlands"},{"name":"Department of Orthopedics University Medical Center Utrecht  Utrecht 3508 The Netherlands"},{"name":"Department of Clinical Sciences Faculty of Veterinary Medicine Utrecht University  Utrecht 3584 The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8740-2464","authenticated-orcid":false,"given":"Marco C.","family":"Bottino","sequence":"additional","affiliation":[{"name":"Department of Cariology Restorative Sciences and Endodontics School of Dentistry University of Michigan  Ann Arbor MI 48109 USA"},{"name":"Department of Biomedical Engineering College of Engineering University of Michigan  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