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Synthesized from copolymerization of diacetone acrylamide (D<jats:styled-content>A<\/jats:styled-content>AM), di(ethylene glycol) ethyl ether acrylate, and oligo(ethylene glycol) methyl ether acrylate, PADO polymer phase separates at temperature above its lower critical solution temperature (36\u201342\u00a0\u00b0C) due to enhanced hydrophobic interactions between the short ethylene glycol side chains. Solution of PADO polymers exhibit injectable shear\u2010thinning properties and reach sol\u2013gel transition rapidly (&lt;5\u00a0min) at 37\u00a0\u00b0C.\u00a0When\u00a0the ketone moieties on DAAM are linked by adipic acid dihydrazdie, PADO polymers form crosslinked and injectable acylhydrazone hydrogels, which are hydrolytically degradable at a mild acidic environment owing to the pH sensitive acylhydrazone bonds. The pH\u2010responsive degradation kinetics can be controlled by tuning polymer contents and ketone\/hydrazide ratio. Importantly, the injectable PADO hydrogels are highly cytocompatible and can be easily formulated for pH\u2010responsive sustained protein delivery.<\/jats:p>","DOI":"10.1002\/adhm.202101284","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T03:51:28Z","timestamp":1633492288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Injectable Acylhydrazone\u2010Linked RAFT Polymer Hydrogels for Sustained Protein Release and Cell Encapsulation"],"prefix":"10.1002","volume":"11","author":[{"given":"Fang\u2010Yi","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Purdue School of Engineering &amp; Technology Indiana University\u2010Purdue University Indianapolis  Indianapolis IN 46202 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan H.","family":"Dimmitt","sequence":"additional","affiliation":[{"name":"Department of 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