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There is a strong clinical demand for more effective treatments for IVDD as conventional treatments provide only symptomatic relief rather than arresting IVDD progression. This study shows that senolytic therapy with local drug delivery can inhibit IVDD and restore IVD integrity. ABT263, a senolytic drug, is loaded in poly(lactic\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u2010glycolic acid) nanoparticles (PLGA\u2010ABT) and intradiscally administered into injury\u2010induced IVDD rat models. The single intradiscal injection of PLGA\u2010ABT may enable local delivery of the drug to avascular IVD, prevention of potential systemic toxicity caused by systemic administration of senolytic drug, and morbidity caused by repetitive injections of free drug into the IVD. The strategy results in the selective elimination of senescent cells from the degenerative IVD, reduces expressions of pro\u2010inflammatory cytokines and matrix proteases in the IVD, inhibits progression of IVDD, and even restores the IVD structure. This study demonstrates for the first time that local delivery of senolytic drug can effectively treat senescence\u2010associated IVDD. This approach can be extended to treat other types of senescence\u2010associated degenerative diseases.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202101483","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T15:04:15Z","timestamp":1635260655000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Local Delivery of Senolytic Drug Inhibits Intervertebral Disc Degeneration and Restores Intervertebral Disc Structure"],"prefix":"10.1002","volume":"11","author":[{"given":"Songhyun","family":"Lim","sequence":"first","affiliation":[{"name":"School of Chemical and Biological Engineering Seoul National University  Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Bae","family":"An","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery CHA University School of Medicine  CHA Bundang Medical Center, Seongnam\u2010si Gyeonggi\u2010do 13496 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mungyo","family":"Jung","sequence":"additional","affiliation":[{"name":"School of Chemical and Biological Engineering Seoul National University  Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Prasad","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery CHA University School of Medicine  CHA Bundang Medical Center, Seongnam\u2010si Gyeonggi\u2010do 13496 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER)\u2010Ahmedabad  Gandhinagar Gujarat 382355 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheesue","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Chemical and Biological Engineering Seoul National University  Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seuk Young","family":"Song","sequence":"additional","affiliation":[{"name":"School of Chemical and Biological Engineering Seoul National University  Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u2010Ro","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Chemical and Biological Engineering Seoul National University  Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikyung","family":"Kang","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program for Bioengineering Seoul National University  Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inbo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery CHA University School of Medicine  CHA Bundang Medical Center, Seongnam\u2010si Gyeonggi\u2010do 13496 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5210-7430","authenticated-orcid":false,"given":"Byung\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Chemical and Biological Engineering Seoul National University  Seoul 08826 Republic of Korea"},{"name":"Interdisciplinary Program for Bioengineering Seoul National University  Seoul 08826 Republic of Korea"},{"name":"Institute of Chemical Processes Institute of Engineering Research BioMAX Seoul National University  Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v4.i2.42"},{"key":"e_1_2_9_2_1","volume":"88","author":"Larson J. 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