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Herein, enzymatic activity is introduced into the zeolitic imidazolate framework\u20108 (ZIF\u20108) to achieve sterilization by releasing Zn ions, as well as inflammation regulation through the variable valence of Mn ions that are uniformly doped into its framework. Within this simple metal organic framework (MOF) structure design, Mn\u2010ZIF\u20108 possesses the co\u2010existence of Mn<jats:sup>2+<\/jats:sup>\/Mn<jats:sup>4+<\/jats:sup> to endow the nanocomposite with the anti\u2010inflammatory capabilities, which can be adjusted through the redox environment. The enzymatic activity of Mn ions and superiority of pore structure of ZIF\u20108 are effectively combined to realize the substrate selection via reactant molecular size and high\u2010efficiency internal catalytic performance. By such design, this nanocomposite would not only exhibit an excellent antibacterial performance against pathogenic bacteria, but also reshape the inflammatory immunity by regulating macrophage polarization to suppress over\u2010reacted inflammation, leading to a favorably therapeutic efficiency on bacteria\u2010infected wound healing in animal models. Taken together, this nanoplatform provides effective approach for accelerating infected wound healing via bacteria killing and inflammation modulation, and may be extended for the therapy of other severe bacteria\u2010induced infections.<\/jats:p>","DOI":"10.1002\/adhm.202101515","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T18:18:31Z","timestamp":1632507511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":169,"title":["Antibacterial Zeolite Imidazole Frameworks with Manganese Doping for Immunomodulation to Accelerate Infected Wound Healing"],"prefix":"10.1002","volume":"10","author":[{"given":"Yao","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Oral Implantology Hospital of Stomatology Jilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering Jilin University  Changchun 130021 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