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Sufferers report difficulty with speech and oral food processing and collectively is detrimental to quality of life. Polyethylene glycol (PEG) is widely employed as a successful biocompatible boundary lubricant in engineering and biomedical applications. It is hypothesized that the immobilization of PEG to biological materials such as oral epithelial cells and tissue can mimic the salivary film and provide durable relief from the symptoms of mucosal dryness. To do so, PEG is functionalized with a sugar binding lectin (wheat germ agglutinin) to enhance epithelial adhesion through lectin\u2010sugar interactions. Retention and lubricity are characterized on an ex vivo oral tissue tribology rig. WGA\u2010PEG coats and retains on mucin films, oral epithelial cells, and porcine tongue tissue, and offers sustained reduction in coefficient of friction (COF). WGA\u2010PEG could be developed into a useful topical treatment for reducing oral friction and the perception of dry mouth.<\/jats:p>","DOI":"10.1002\/adhm.202101719","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T14:09:50Z","timestamp":1635430190000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lectin\u2010Functionalized Polyethylene Glycol for Relief of Mucosal Dryness"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8464-9530","authenticated-orcid":false,"given":"Matthew","family":"Blakeley","sequence":"first","affiliation":[{"name":"Division of Glycoscience Department of Chemistry School of Engineering Sciences in Chemistry Biotechnology and Health KTH \u2013 Royal Institute of Technology AlbaNova University Centre  Stockholm 106 91 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8342-8939","authenticated-orcid":false,"given":"Prashant K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Groningen and University Medical Centre Groningen  Groningen 9713 AV The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans J.","family":"Kaper","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Groningen and University Medical Centre Groningen  Groningen 9713 AV The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-3556","authenticated-orcid":false,"given":"Nagihan","family":"Bostanci","sequence":"additional","affiliation":[{"name":"Division of Oral Diseases Department of Dental Medicine Karolinska Institutet  Huddinge 141 52 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1981-3736","authenticated-orcid":false,"given":"Thomas","family":"Crouzier","sequence":"additional","affiliation":[{"name":"Division of Glycoscience Department of Chemistry School of Engineering Sciences in Chemistry Biotechnology and Health KTH \u2013 Royal Institute of Technology AlbaNova University Centre  Stockholm 106 91 Sweden"},{"name":"AIMES \u2013 Center for the Advancement of Integrated Medical and Engineering Sciences at Karolinska Institutet and KTH \u2013 Royal Institute of Technology  Stockholm 114 28 Sweden"},{"name":"Department of Neuroscience Karolinska Institutet  Stockholm 171 77 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2017.04.001"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12194"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153273"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/08927010310001618571"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12867"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2018.08.010"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.57.030195.002555"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0242832"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66990-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22302"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.04.021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10129"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)00415-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.12.012"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12402"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.2005.00087.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04908-9"},{"key":"e_1_2_8_18_1","author":"Furness S.","year":"2011","journal-title":"Cochrane Database Syst. 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