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In this contribution, dopamine\u2010modified hyaluronic acid (HA\u2010DA) is developed as the backbone for an injectable hydrogel using a catechol\u2013Fe<jats:sup>3+<\/jats:sup> coordination crosslinking strategy. Due to dynamic physical crosslinking, the hydrogel can be easily injected through a single syringe. Into the hydrogel, black phosphorous nanosheets loaded with a Zr\u2010based porphyrinic metal\u2212organic framework (PCN@BP) are introduced that could generate reactive oxygen species (ROS) under 660\u00a0nm laser irradiation, this promotes the oxidative coupling of dopamine in the presence of the ROS, introducing in situ chemical crosslinking into the hydrogel. A physical\/chemical double\u2010crosslinked hydrogel is obtained, effectively improving the hydrogel's mechanical properties, which are tuned in situ by adjusting the irradiation time to match the mechanical modulus of different biological tissues. Combining the excellent photothermal properties and photodynamic performance of the PCN@BP nanosheets yields effective sterilization under mild conditions (below 50 \u00b0C, low ROS production). The results show that this hydrogel is an excellent multifunctional wound dressing.<\/jats:p>","DOI":"10.1002\/adhm.202101722","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T12:51:34Z","timestamp":1632747094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Dual\u2010Light\u2010Triggered In Situ Structure and Function Regulation of Injectable Hydrogels for High\u2010Efficient Anti\u2010Infective Wound Therapy"],"prefix":"10.1002","volume":"11","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering Engineering Research Center of Dairy Quality and Safety Control Technology Ministry of Education Inner Mongolia University  235 University West Street Hohhot 010021 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