{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:16:32Z","timestamp":1790100992887,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019822","name":"Temasek Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFE0204300"],"award-info":[{"award-number":["2020YFE0204300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Disinfection using effective antimicrobials is essential in preventing the spread of infectious diseases. This COVID\u201019 pandemic has brought the need for effective disinfectants to greater attention due to the fast transmission of SARS\u2010CoV\u20102. Current active ingredients in disinfectants are small molecules that microorganisms can develop resistance against after repeated long\u2010term use and may penetrate the skin, causing harmful side\u2010effects. To this end, a series of membrane\u2010disrupting polyionenes that contain quaternary ammoniums and varying hydrophobic components is synthesized. They are effective against bacteria and fungi. They are also fast acting against clinically isolated drug resistant strains of bacteria. Formulating them with thickeners and nonionic surfactants do not affect their killing efficiency. These polyionenes are also effective in preventing infections caused by nonenveloped and enveloped viruses. Their effectiveness against mouse coronavirus (i.e., mouse hepatitis virus\u2010MHV) depends on their hydrophobicity. The polyionenes with optimal compositions inactivates MHV completely in 30 s. More importantly, the polyionenes are effective in inhibiting SARS\u2010CoV\u20102 by &gt;99.999%\u00a0within 30 s. While they are effective against the microorganisms, they do not cause damage to the skin and have a high oral lethal dose. Overall, these polyionenes are promising active ingredients for disinfection and prevention of viral and microbial infections.<\/jats:p>","DOI":"10.1002\/adhm.202101898","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T09:07:31Z","timestamp":1635152851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Potent Antiviral and Antimicrobial Polymers as Safe and Effective Disinfectants for the Prevention of Infections"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4895-4044","authenticated-orcid":false,"given":"Jiayu","family":"Leong","sequence":"first","affiliation":[{"name":"Institute of Bioengineering and Bioimaging  31 Biopolis Way, The Nanos Singapore 138669 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danrong","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases First Affiliated Hospital Zhejiang University School of Medicine  79 Qingchun Road Hangzhou 310003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy Pang Kern","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering and Bioimaging  31 Biopolis Way, The Nanos Singapore 138669 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering and Bioimaging  31 Biopolis Way, The Nanos Singapore 138669 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengcai","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering and Bioimaging  31 Biopolis Way, The Nanos Singapore 138669 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering and Bioimaging  31 Biopolis Way, The Nanos Singapore 138669 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeen Shian","family":"Ngow","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Singapore General Hospital  Outram Road Singapore 169608 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Kng","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering and Bioimaging  31 Biopolis Way, The Nanos Singapore 138669 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nithiyaa","family":"Balakrishnan","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering and Bioimaging  31 Biopolis Way, The Nanos Singapore 138669 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu Qin","family":"Peng","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering and Bioimaging  31 Biopolis Way, The Nanos Singapore 138669 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Siang","family":"Yeow","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering and Bioimaging  31 Biopolis Way, The Nanos Singapore 138669 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balamurugan","family":"Periaswamy","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering and Bioimaging  31 Biopolis Way, The Nanos Singapore 138669 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrinivas","family":"Venkataraman","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering and Bioimaging  31 Biopolis Way, The Nanos Singapore 138669 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Lay\u2010Hoon","family":"Kwa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Singapore General Hospital  Outram Road Singapore 169608 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases First Affiliated Hospital Zhejiang University School of Medicine  79 Qingchun Road Hangzhou 310003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangping","family":"Yao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases First Affiliated Hospital Zhejiang University School of Medicine  79 Qingchun Road Hangzhou 310003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1871-5448","authenticated-orcid":false,"given":"Yi Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering and Bioimaging  31 Biopolis Way, The Nanos Singapore 138669 Singapore"},{"name":"Department of Orthopaedic Surgery Yong Loo Lin School of Medicine National University of Singapore  Singapore 119288 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.058"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0026360"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2009.03.012"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2010.08.011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2012.12.028"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2011.04.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aar6115"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2000.009003165.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/es401507k"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120078"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b19313"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b19712"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07651-7"},{"key":"e_1_2_9_11_3","doi-asserted-by":"publisher","DOI":"10.1007\/s10853-012-6854-8"},{"key":"e_1_2_9_11_4","doi-asserted-by":"publisher","DOI":"10.1039\/C8PY00665B"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2018.02.001"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202000063"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.02.027"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.07.038"},{"key":"e_1_2_9_13_3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b00489"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/10915819309140642"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100482"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200801523"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c01320"},{"key":"e_1_2_9_16_3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1704489114"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-0695-z"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/v12080880"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805270106"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.6b00091"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2012.07.005"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1662"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2011.148"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-007-9057-9"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780471729259.mc15e01s21"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-020-00226-1"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.018"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1787\/9789264071049-en"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202101898","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202101898","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202101898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T19:37:24Z","timestamp":1759779444000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202101898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,8]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/adhm.202101898"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202101898","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,8]]},"assertion":[{"value":"2021-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2101898"}}