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Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) is a significant gaseous signaling molecule with intrinsic biochemical properties, which exerts its various physiological effects under both normal and pathological conditions. Various nanomaterials with H<jats:sub>2<\/jats:sub>S\u2010responsive properties, as new\u2010generation therapeutic agents, are explored to guide therapeutic behaviors in biological milieu. The cross disciplinary of H<jats:sub>2<\/jats:sub>S is an emerging scientific hotspot that studies the chemical properties, biological mechanisms, and therapeutic effects of H<jats:sub>2<\/jats:sub>S. This review summarizes the state\u2010of\u2010art research on H<jats:sub>2<\/jats:sub>S\u2010related nanomedicines. 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