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However, most of phototherapeutic agents still suffer from low photothermal conversion efficacy and photodynamic performance, poor biocompatibility, and intratumor accumulation. Herein a biocompatible and target\u2010deliverable PTT\u2013PDT self\u2010synergetic nanoplatform of RGD\u2010BPNS@SMFN based on temperature\u2010dependent catalase (CAT)\u2010like behavior for tumor elimination is presented. The homogeneously dispersible nanoplatform is designed and fabricated through anchoring spherical manganese ferrite nanoparticles (SMFN) to black phosphorus nanosheets (BPNS), followed by arginine\u2013glycine\u2013aspartic acid (RGD) peptide modification. The nanoplatform exhibits excellent targeting ability and enhanced photonic response in comparison to plain BPNS and SMFN in vitro and in vivo. It is found that PTT and PDT have a self\u2010synergetic behavior by means of the dual phototherapy mode interaction. The self\u2010synergetic mechanism is mainly ascribed to PTT\u2010promoted inherent CAT\u2010like activity in the nanoplatform, which remodels the tumor hypoxia microenvironment and further ameliorates the PDT efficiency, providing promising high performance nanoplatform for synergetic dual mode phototherapy, enriching the design for the antitumor nanozyme.<\/jats:p>","DOI":"10.1002\/adhm.202102298","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T23:58:55Z","timestamp":1639699135000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Temperature\u2010Dependent CAT\u2010Like RGD\u2010BPNS@SMFN Nanoplatform for PTT\u2010PDT Self\u2010Synergetic Tumor Phototherapy"],"prefix":"10.1002","volume":"11","author":[{"given":"Luping","family":"Song","sequence":"first","affiliation":[{"name":"Institute of Advanced Cross\u2010field Science College of Life Science Qingdao University  Qingdao 266071 P. 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