{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:33:11Z","timestamp":1789691591823,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32130062"],"award-info":[{"award-number":["32130062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21DZ1205600"],"award-info":[{"award-number":["21DZ1205600"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The treatment of severe burn injuries is a crucial challenge in skin tissue engineering. Severe burns are always accompanied with large\u2010area neurovascular networks damage, leading to the lack of excitation functions and difficulty in self\u2010healing. Therefore, it is of great importance to develop biomaterials which can not only promote wound healing but also simultaneously reconstruct cutaneous neurovascular networks. In this study, Zn<jats:sub>2<\/jats:sub>SiO<jats:sub>4<\/jats:sub> (ZS) nanoparticles\u2010incorporated bioactive nanofibrous scaffolds are designed for innervated and vascularized skin burn wound healing. ZS nanoparticles with spindle\u2010like morphology are synthesized via a facile hydrothermal method. The incorporation of ZS nanoparticles endows the scaffolds with excellent angiogenic and neurogenic activities in vitro. Additionally, in vivo results show that the ZS nanoparticles\u2010incorporated scaffolds have favorable re\u2010epithelialization, innervation, and vascularization abilities through local release of bioactive Zn and Si ions from ZS nanoparticles, leading to rapid wound healing featuring with newly formed blood vessels and nerve fibers. Taken together, this study suggests that the spindle\u2010like ZS nanoparticles are useful bioactive agents for stimulating vascularization and innervation of functional skin repair. The bioactive inorganic nanoparticles may be used for multifunctional tissue regeneration.<\/jats:p>","DOI":"10.1002\/adhm.202102359","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T15:39:36Z","timestamp":1643729976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Spindle\u2010Like Zinc Silicate Nanoparticles Accelerating Innervated and Vascularized Skin Burn Wound Healing"],"prefix":"10.1002","volume":"11","author":[{"given":"Hongjian","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenping","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongshi","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Qin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajie","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5986-591X","authenticated-orcid":false,"given":"Chengtie","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2014.02.001"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00656-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2012-0181"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116175"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.117484"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.06.030"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.02.004"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900513"},{"key":"e_1_2_8_5_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.130634"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2321"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2013.0535"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202001751"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB01100B"},{"key":"e_1_2_8_7_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c17142"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02598-7"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.05.028"},{"key":"e_1_2_8_8_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.04.008"},{"key":"e_1_2_8_8_4","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201600245"},{"key":"e_1_2_8_8_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120164"},{"key":"e_1_2_8_8_6","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202102981"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.10.018"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.09.038"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120414"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b08928"},{"key":"e_1_2_8_10_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.07.020"},{"key":"e_1_2_8_10_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.04.005"},{"key":"e_1_2_8_10_5","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201800776"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10010016"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.12.006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-016-1689-0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2015.05.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jace.12027"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.07.013"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8NR09818B"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100523"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.125617"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121225"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00279.2017"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14060"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.8b01564"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12647"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01488-2"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b17801"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4321"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4322"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1012"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2021.129629"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb1311"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11268"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkab004"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26889"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.06.021"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202102359","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202102359","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202102359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T15:13:49Z","timestamp":1759763629000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202102359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,9]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/adhm.202102359"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202102359","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,9]]},"assertion":[{"value":"2021-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2102359"}}