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However, existing immunomodulatory hydrogels lack interconnected micropores to promote cell ingrowth. Other limitations include invasive delivery procedures and harsh synthesis conditions that are incompatible with drug molecules.\u00a0Here, hybrid nanocomposite microgels containing interleukin\u201010 (IL\u201010) are reported to modulate tissue macrophage phenotype during wound healing. The intercalation of laponite nanoparticles in the polymer network yields microgels with tissue\u2010mimetic elasticity (Young's modulus in the range of 2\u20136\u00a0kPa) and allows the sustained release of IL\u201010 to promote the differentiation of macrophages toward proregenerative phenotypes. The porous interstitial spaces between microgels promote fibroblast proliferation and fast trafficking (an average speed of \u224814.4\u00a0\u00b5m h\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). The\u00a0incorporation of hyaluronic acid further enhances macrophage infiltration. The coculture of macrophages and fibroblasts treated with transforming growth factor\u2010beta 1 resulted in a twofold reduction in collagen\u2010I production for microgels releasing IL\u201010 compared to the IL\u201010 free group. The new microgels show potential toward regenerative healing by harnessing the antifibrotic behavior of host macrophages.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202102366","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T03:19:36Z","timestamp":1644031176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Immunomodulatory Microgels Support Proregenerative Macrophage Activation and Attenuate Fibroblast Collagen Synthesis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6247-5867","authenticated-orcid":false,"given":"Sepideh","family":"Mohammadi","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering McGill University  Montreal QC H3A 0C3 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