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One potential strategy to conquer this limitation is the fabrication of spontaneous and continuous oxygen supplying scaffolds for in situ tissue regeneration. In this work, a versatile fluorine\u2010incorporating hydrogel is designed which can not only timely and continuously supply oxygen for mesenchymal stem cells (MSCs) to overcome deficient oxygen before vascularization in scaffolds, but can present a higher antibacterial capability to avoid bacterial infections. The HAp@PDA\u2010F nanoparticles are first prepared and then incorporated with the quaternized and methacrylated chitosan forming CS\/HAp@PDA\u2010F by photo\u2010crosslinking. In vitro results indicate that CS\/HAp@PDA\u2010F hydrogel has outstanding mechanical performance, moreover, it also has the oxygen\u2010carrying ability to prolong survival ability, enhance proliferation activity, and preserve osteogenic differentiation potency and promote osteogenic\u2010related genes expression of rat bone mesenchymal stem cells (rBMSCs) under hypoxic environment. Furthermore, the CS\/HAp@PDA\u2010F hydrogel can inhibit the growth of <jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>Escherichia coli<\/jats:italic>, providing a good antibacterial activity. Additionally, in vivo experiments demonstrate higher bone volume and bone mineral density, and more new bone tissue generation in CS\/HAp@PDA\u2010F group than in CS\/HAp@PDA group. These results indicate that the rational design of fluorinated hydrogel possesses a good clinical application prospect for bone regeneration.<\/jats:p>","DOI":"10.1002\/adhm.202102540","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T07:09:55Z","timestamp":1644908995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Oxygen\u2010Carrying and Antibacterial Fluorinated Nano\u2010Hydroxyapatite Incorporated Hydrogels for Enhanced Bone Regeneration"],"prefix":"10.1002","volume":"11","author":[{"given":"Baoxuan","family":"Huang","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Functional Materials Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology  Meilong Road No. 130 Shanghai 200237 P. R. 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