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Despite the assortment available on the market, sutures are still affected by significant disadvantages, including failure in mimicking the mechanical properties of the tissue, excessive fibrosis, and inflammation. This study introduces a mandrel\u2010less electrodeposition apparatus to fabricate continuous microfiber wires of indefinite length. The mandrel\u2010less biofabrication produces wires, potentially used as medical fibers, with different microfiber bundles, that imitate the hierarchical organization of native tissues, and tailored mechanical properties. Microfiber wire morphology and mechanical properties are characterized by scanning electron microscopy, digital image processing, and uniaxial tensile test. Wires are tested in vitro on monocyte\/macrophage stimulation and in vivo on a rat surgical wound model. The wires produced by mandrel\u2010less deposition show an increased M2 macrophage phenotype in vitro. The in vivo assessment demonstrates that microfiber wires, compared to the medical fibers currently used, reduce pro\u2010inflammatory macrophage response and preserve their mechanical properties after 30 days of use. These results make this microfiber wire an ideal candidate as a suture material for soft tissue surgery, suggesting a crucial role of microarchitecture in more favorable host response.<\/jats:p>","DOI":"10.1002\/adhm.202102613","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T09:58:47Z","timestamp":1649411927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Continuous Microfiber Wire Mandrel\u2010Less Biofabrication for Soft Tissue Engineering Applications"],"prefix":"10.1002","volume":"11","author":[{"given":"Arianna","family":"Adamo","sequence":"first","affiliation":[{"name":"McGowan Institute for Regenerative Medicine  Pittsburgh PA 15219 USA"},{"name":"Ri. 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