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To overcome this dilemma, nanodrug with the ability of ECs targeted glycolysis inhibition and nanodrug with the ability of tumor cell glycolysis inhibition, anti\u2010VEGF, and MET are combined to prepare Nano\u2010combination the pathways related to angiogenesis, tumor cell proliferation, and immunosuppression and breaking the negative sugar\u2010lipid\u2010protein metabolism balance in tumor microenvironment. Thus, stronger and more lasting normalized tumor vascular network and remarkable antitumor efficacy are obtained after treatment, constructing a positive feedback loop between TVNT and anti\u2010tumor therapy. 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