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Even though tissue adhesive opens a new era for wound closure, the method and biomaterial that can simultaneously achieve noninvasive wound closure and promote wound healing are highly appreciated. Herein, a novel supramolecular poly(N\u2010isopropylacrylamide) hybrid hydrogel dressing composed of quaternized chitosan\u2010graft\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010cyclodextrin, adenine, and polypyrrole nanotubes via host\u2013guest interaction and hydrogen bonds is developed. The hydrogel demonstrates thermal contraction of 47% remaining area after 2 h at 37\u00a0\u2103 and tissue adhesion of 5.74\u00a0kPa, which are essential for noninvasive wound closure, and multiple mechanical and biological properties including suitable mechanical properties, self\u2010healing, on\u2010demand removal, antioxidant, hemostasis, and photothermal\/intrinsic antibacterial activity (higher 99% killing ratio within 5 min after irradiation). In both full\u2010thickness skin incision and excision wound models, the hydrogel reveals significant wound closure after 24 h post\u2010surgery. In acute and methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureu<\/jats:italic>\n                    s\u2010infected wound and photothermal\/intrinsic antibacterial activity assays, wounds treated with the hydrogel demonstrate enhanced wound healing with rapid wound closure rate, mild inflammatory response, advanced angiogenesis, and well\u2010arranged collagen fibers. Altogether, the results indicate the hydrogel is promising in synchronously noninvasive wound closure and enhanced wound healing.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202102749","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T04:56:36Z","timestamp":1649998596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":186,"title":["Supramolecular Thermo\u2010Contracting Adhesive Hydrogel with Self\u2010Removability Simultaneously Enhancing Noninvasive Wound Closure and MRSA\u2010Infected Wound Healing"],"prefix":"10.1002","volume":"11","author":[{"given":"Rui","family":"Yu","sequence":"first","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University  Xi'an 710049 China"},{"name":"Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials 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