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While antibacterial coatings fabricated by layer\u2010by\u2010layer (LBL) assembly techniques have been well explored, the facile preparation of substrate\u2010independent smart antibacterial coatings with on\u2010demand antibiotics release profile and excellent antibacterial performance is still urgently needed. In this work, this goal is addressed by LBL assembly fabrication of robust antibacterial coatings using naturally occurring and commercially available building blocks (i.e., aminoglycosides, 5,6\u2010dihydroxyindole, and formylphenylboronic acid) via the subsequentially performed mussel\u2010inspired polymerization and dynamic covalent chemistries. The resulting antibacterial coatings on different substates all presente a dynamic feature (i.e., pH\u2010responsive), on\u2010demand antibiotics release properties, and highly effective antibacterial performance both in vitro and in vivo. It is envisioned that this work can expand the scope of LBL assembly technique toward the next generation of robust and universal antibacterial coating materials by using natural building blocks and readily available chemistries.<\/jats:p>","DOI":"10.1002\/adhm.202200112","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T13:33:51Z","timestamp":1645277631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Layer\u2010by\u2010Layer Assembled Smart Antibacterial Coatings via Mussel\u2010Inspired Polymerization and Dynamic Covalent Chemistry"],"prefix":"10.1002","volume":"11","author":[{"given":"Lei","family":"Yang","sequence":"first","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University  Chengdu 610065 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