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However, the effect of photothermal\/photodynamic therapy (PTT\/PDT) is restricted by limited tumor penetration depth and unsatisfactory potentiation of antitumor immunity. Here, a near\u2010infrared (NIR)\u2010driven nanomotor is constructed with a mesoporous silicon nanoparticle (MSN) as the core, end\u2010capped with\n                    <jats:italic>Antheraea pernyi<\/jats:italic>\n                    silk fibroin (ApSF) comprising arginine\u2013glycine\u2013aspartate (RGD) tripeptides. Upon NIR irradiation, the resulting ApSF\u2010coated MSNs (DIMs) loading with photosensitizers (ICG derivatives, IDs) and chemotherapeutic drugs (doxorubicin, Dox) can efficiently penetrate into the internal tumor tissues and achieve effective phototherapy. Combined with chemotherapy, a triple\u2010modal treatment (PTT, PDT, and chemotherapy) approach is developed to induce the immunogenic cell death of tumor cells and to accelerate the release of damage\u2010associated molecular patterns. In vivo results suggest that DIMs can promote the maturation of dendritic cells and surge the number of infiltrated immune cells. Meanwhile, DIMs can polarize macrophages from M2 to M1 phenotypes and reduce the percentages of immunosuppressive Tregs, which reverse the immunosuppressive tumor microenvironment and activate systemic antitumor immunity. By achieving synergistic effects on the tumor inhibition and the antitumor immunity activation, DIMs show great promise as new nanoplatforms to treat metastatic breast cancer.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202200255","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T13:59:26Z","timestamp":1652191166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Near\u2010Infrared\u2010Enpowered Nanomotor\u2010Mediated Targeted Chemotherapy and Mitochondrial Phototherapy to Boost Systematic Antitumor Immunity"],"prefix":"10.1002","volume":"11","author":[{"given":"Xueqing","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology College of Sericulture Textile and Biomass Sciences Southwest University  Chongqing 400715 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"He","sequence":"additional","affiliation":[{"name":"West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1274-5080","authenticated-orcid":false,"given":"Jianfeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences University of Oxford  Headington Oxford OX3 7LD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlin","family":"Gong","sequence":"additional","affiliation":[{"name":"West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingui","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology College of Sericulture Textile and Biomass Sciences Southwest University  Chongqing 400715 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Duan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology College of Sericulture Textile and Biomass Sciences Southwest University  Chongqing 400715 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0922-9904","authenticated-orcid":false,"given":"Shixiong","family":"Yi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology College of Sericulture Textile and Biomass Sciences Southwest University  Chongqing 400715 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binwu","family":"Ying","sequence":"additional","affiliation":[{"name":"West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2992-6435","authenticated-orcid":false,"given":"Bo","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology College of Sericulture Textile and Biomass Sciences Southwest University  Chongqing 400715 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,18]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-020-0448-9"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0623-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.12.018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.12.018"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0308-z"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2018.07.005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202003748"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b07212"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00271E"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202001088"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11269-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201902634"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12851"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.09.005"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2020.1748005"},{"key":"e_1_2_8_16_1","first-page":"467","volume":"42","author":"Rossmanna C.","year":"2014","journal-title":"Crit. 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