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In this study, a photosensitizer\u2010polypeptide conjugate (PPa\u2010cP) comprising a photosensitizer, pyropheophorbide a (PPa), and a cationic polypeptide (cP) is readily synthesized for effective antifungal and antibiofilm treatment. Compared with free PPa, the cationic PPa\u2010cP shows enhanced binding ability to the negatively charged surface of\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    (\n                    <jats:italic>C. albicans<\/jats:italic>\n                    ) through electrostatic interactions. As a result, PPa\u2010cP exhibits effective antifungal efficiency against both\n                    <jats:italic>C. albicans<\/jats:italic>\n                    and fluconazole\u2010resistant\n                    <jats:italic>C. albicans<\/jats:italic>\n                    in vitro under light irradiation. The minimum inhibitory concentration (MIC) of PPa\u2010cP for both\n                    <jats:italic>C. albicans<\/jats:italic>\n                    and fluconazole\u2010resistant\n                    <jats:italic>C. albicans<\/jats:italic>\n                    is 1\u00a0\u00b5\n                    <jats:sc>m<\/jats:sc>\n                    . In addition, PPa\u2010cP also shows improved penetration in a\n                    <jats:italic>C. albicans<\/jats:italic>\n                    biofilm, thus effectively eliminating the\n                    <jats:italic>C. albicans<\/jats:italic>\n                    biofilm by photodynamic effects. More importantly, PPa\u2010cP demonstrats significantly enhanced therapeutic effects in a fluconazole\u2010resistant\n                    <jats:italic>C. albicans<\/jats:italic>\n                    \u2010infected rat model with minimal side effects. In conclusion, the current work presents an effective strategy to combat biofilm infections associated with biomedical equipment.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202200268","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T08:48:18Z","timestamp":1656319698000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Photosensitizer\u2010Polypeptide Conjugate for Effective Elimination of\n                    <i>Candida albicans<\/i>\n                    Biofilm"],"prefix":"10.1002","volume":"11","author":[{"given":"Pengqi","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Chemistry Northeast Normal University  Changchun 130024 P. R. China"},{"name":"Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P. R. 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