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In this study, a flexible 3D nanonetworked silica film (NSF) capable of withstanding mechanical stress during dynamic expansion is constructed to function as a drug delivery platform on an entire SEMS surface. Despite covering a broad curved area, the synthesized NSF is defect\u2010free and thin enough to increase the stent strut diameter (110\u00a0\u00b5m) by only 0.4 percent (110.45\u00a0\u00b5m). The hydrophobic modification of the surface enables loading of 4.7 times the sirolimus (SRL) concentration in NSF than Cypher, polymer\u2010coated commercial stent, which is based on the same thickness of coating layer. Furthermore, SRL\u2010loaded NSF exhibits a twofold delay in release compared to the control group without NSF. The SRL\u2010loaded NSF SEMS significantly suppresses stent\u2010induced tissue hyperplasia than the control SEMS in the rat esophagus (all variables, <jats:italic>p<\/jats:italic> &lt;\u00a00.05). Thus, the developed NSF is a promising polymer\u2010free drug delivery platform to efficiently treat esophageal stricture.<\/jats:p>","DOI":"10.1002\/adhm.202200389","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T13:11:02Z","timestamp":1652706662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Flexible 3D Nanonetworked Silica Film as a Polymer\u2010Free Drug\u2010Eluting Stent Platform to Effectively Suppress Tissue Hyperplasia in Rat Esophagus"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4338-2075","authenticated-orcid":false,"given":"Eunyoung","family":"Jeon","sequence":"first","affiliation":[{"name":"Department of Chemistry Hanyang University  222 Wangsimni\u2010Ro, Seongdong\u2010Gu Seoul 04763 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6203-6381","authenticated-orcid":false,"given":"Jeon Min","family":"Kang","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Research Center Asan Institute for Life Sciences Asan Medical Center  88 Olympic\u2010ro 43\u2010gil, Songpa\u2010gu Seoul 05505 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6347-2476","authenticated-orcid":false,"given":"Ga\u2010Hyun","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Integrative Biotechnology College of Biotechnology and Bioengineering Sungkyunkwan University  Seoburo 2066, Suwon Gyeonggi 16419 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3364-4649","authenticated-orcid":false,"given":"Chu Hui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Research Center Asan Institute for Life Sciences Asan Medical Center  88 Olympic\u2010ro 43\u2010gil, Songpa\u2010gu Seoul 05505 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9502-2496","authenticated-orcid":false,"given":"Seungyong","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Integrative Biotechnology College of Biotechnology and Bioengineering Sungkyunkwan University  Seoburo 2066, Suwon Gyeonggi 16419 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2514-8805","authenticated-orcid":false,"given":"Byeongdu","family":"Lee","sequence":"additional","affiliation":[{"name":"X\u2010Ray Science Division Argonne National Laboratory  Argonne IL 60439 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4614-0530","authenticated-orcid":false,"given":"Wooram","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Integrative Biotechnology College of Biotechnology and Bioengineering Sungkyunkwan University  Seoburo 2066, Suwon Gyeonggi 16419 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9114-7750","authenticated-orcid":false,"given":"Jung\u2010Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Research Center Asan Institute for Life Sciences Asan Medical Center  88 Olympic\u2010ro 43\u2010gil, Songpa\u2010gu Seoul 05505 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9551-6402","authenticated-orcid":false,"given":"Joonseok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry Hanyang University  222 Wangsimni\u2010Ro, Seongdong\u2010Gu Seoul 04763 Republic of Korea"},{"name":"Research Institute for Convergence of Basic Sciences Hanyang University  222 Wangsimni\u2010Ro, Seongdong\u2010Gu Seoul 04763 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,22]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep1053"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.14309\/00000434-201710001-01738"},{"key":"e_1_2_8_3_1","first-page":"526","volume":"8","author":"Hindy P.","year":"2012","journal-title":"Gastroenterol. 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