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The light\u2010to\u2010heat conversion efficiency under irradiation with an 808\u00a0nm near\u2010infrared laser is as high as 59.28%. The MoSe<jats:sub>2<\/jats:sub>\u2010PVP NPs could function as an artificial catalase and catalyze the decomposition of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. Their catalytic\u00a0activity and thermal durability are higher than the native catalase, which relieve the tumor hypoxia status and sensitize the tumor PDT. The data show that the synthetic MoSe<jats:sub>2<\/jats:sub>\u2010PVP is biodegradable, owing to the oxidation of the Mo<jats:sup>4+<\/jats:sup> to Mo<jats:sup>6+<\/jats:sup>. Moreover, its degradation products could increase the proportion of mature dendritic cells and CD8<jats:sup>+<\/jats:sup> thymus (T) cells and promote the infiltration of active CD8<jats:sup>+<\/jats:sup> T cells in tumors. The immune checkpoint inhibitor, programmed cell death protein 1 monoclonal antibody is combined with MoSe<jats:sub>2<\/jats:sub>\u2010PVP and it is found that its degradation product could efficiently change the immune microenvironment of the tumor.<\/jats:p>","DOI":"10.1002\/adhm.202200524","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T04:44:35Z","timestamp":1653453875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Synthetic and Biodegradable Molybdenum(IV) Diselenide Triggers the Cascade Photo\u2010 and Immunotherapy of Tumor"],"prefix":"10.1002","volume":"11","author":[{"given":"Jiulong","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Changhai Hospital Naval Military Medical University  No. 168 Changhai Road Shanghai 200433 P. R. 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