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However, siRNA therapeutics still have off\u2010target proportion and lack effective quantitative analysis method in vivo. Thus, a novel theragnostic nanoparticle with dual\u2010mode imaging is synthesized for targeted and image\u2010guided siRNA therapy of HCC. Survivin siRNA is carried by Poly\u2010ethylenimine (PEI) and interacted with T7\u2010AIE\/Gd NPs, which are self\u2010assembled of DSPE\u2010PEG\u2010DTPA(Gd), DSPE\u2010PEG\u2010Mal, DSPE\u2010PEG\u2010PEI, and TPE. The resulting theragnostic nanoparticles exhibit lower toxicity and high therapeutic effect, and excellent T1\u2010weighted magnetic resonance imaging (MRI) and aggregation\u2010induced emission (AIE) imaging performance. Moreover, in vivo MRI and AIE imaging indicate that this kind of theragnostic nanoparticles rapidly accumulates in the tumor due to active targeting and enhanced permeability and retention (EPR) effects. Sur@T7\u2010AIE\u2010Gd suppresses HCC tumor growth by inducing autophagy and destabilizes DNA integrity in tumor cells. The results suggest that T7\u2010AIE\u2010Gd nanoparticles carrying Survivin siRNA with dual\u2010mode imaging characteristics are promising for targeted and image\u2010guided siRNA therapy of hepatocellular carcinoma.<\/jats:p>","DOI":"10.1002\/adhm.202200579","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T16:57:51Z","timestamp":1656089871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Aggregation\u2010Induced Emission (AIE) and Magnetic Resonance Imaging Characteristics for Targeted and Image\u2010Guided siRNA Therapy of Hepatocellular Carcinoma"],"prefix":"10.1002","volume":"11","author":[{"given":"Yu\u2010chen","family":"Hou","sequence":"first","affiliation":[{"name":"Shanghai Institute of Transplantation  Shanghai 200127 China"},{"name":"Department of Liver Surgery Renji Hospital School of Medicine Shanghai Jiao Tong University  Shanghai 200127 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