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Herein, a heterostructured coating consisting of simvastatin (SIM)\u2010laden metal\u2013organic frameworks and polydopamine nanolayers is created on a porous bioinert polyetheretherketone implant. The heterostructured coating significantly promotes cytocompatibility and osteogenic differentiation through multimodal osteogenicity mechanisms of zinc ion (Zn<jats:sup>2+<\/jats:sup>) therapy, SIM drug therapy, and surface micro\u2010\/nano\u2010topological stimulation. Under the illumination of near\u2010infrared (NIR) light, singlet oxygen (<jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub>) and local hyperthermia are produced; besides, NIR light dramatically accelerates the release of Zn<jats:sup>2+<\/jats:sup> ions from heterostructured coatings. Gram\u2010positive and \u2010negative bacteria are effectively eradicated by the synergy of photothermal\/photodynamic effects and photo\u2010induced accelerated delivery of Zn<jats:sup>2+<\/jats:sup> ions. The superior osteogenicity and osseointegration, as well as photoswitchable disinfection controlled by NIR light are corroborated via in vivo results. This work highlights the great potential of photoresponsive heterostructured orthopedic implants in treatment of the noninvasive bone reconstruction of bacteria\u2010associated infectious tissues through multimodal phototherapy and photoswitchable ion\u2010therapy.<\/jats:p>","DOI":"10.1002\/adhm.202200641","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T06:52:25Z","timestamp":1651819945000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Heterostructured Metal\u2013Organic Frameworks\/Polydopamine Coating Endows Polyetheretherketone Implants with Multimodal Osteogenicity and Photoswitchable Disinfection"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1765-5244","authenticated-orcid":false,"given":"Yi","family":"Deng","sequence":"first","affiliation":[{"name":"College of Biomedical Engineering School of Chemical Engineering Sichuan 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