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Herein, manganese ions, iron ions, or cobalt ions and tetrasulfide bonds are co\u2010incorporated into the framework of DMOS to yield multifunctional nanoparticles denoted as Mn\u2010DMOS, Fe\u2010DMOS, or Co\u2010DMOS by directly doping metal ions during the synthetic process. Due to co\u2010incorporation of metal ions and tetrasulfide bonds, these designed nanocarriers have more functions rather than only for cargo delivery. As proof of concept, the nanocomposite is established based on Mn\u2010DMOS as an efficient nanocarrier for indocyanine green (ICG) delivery and modification with polyethylene glycol. In the tumor microenvironment, the generated hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) arising from the reaction between tetrasulfide bond and over\u2010expressed glutathione (GSH) causes mitochondrial injury to reduce cellular respiration. The released Mn<jats:sup>2+<\/jats:sup> from the rapidly decomposed nanocomposite catalyzes the endogenous hydrogen peroxide to produce oxygen (O<jats:sub>2<\/jats:sub>). The photothermal effect from the released ICG initiated by the near\u2010infrared light induces cancer cells apoptosis and simultaneously enhances the content of blood O<jats:sub>2<\/jats:sub> at tumor sites. Therefore, due to the GSH depletion and trimodal O<jats:sub>2<\/jats:sub> compensation, the photodynamic therapy efficiency of ICG has significantly improved. In brief, these designed nanocarriers will play advanced roles in cancer therapy.<\/jats:p>","DOI":"10.1002\/adhm.202200665","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T21:14:58Z","timestamp":1653426898000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Mn<sup>2+<\/sup>\/Fe<sup>3+<\/sup>\/Co<sup>2+<\/sup> and Tetrasulfide Bond Co\u2010Incorporated Dendritic Mesoporous Organosilica as Multifunctional Nanocarriers: One\u2010Step Synthesis and Applications for Cancer Therapy"],"prefix":"10.1002","volume":"11","author":[{"given":"Bin","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. China"},{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P. R. China"},{"name":"Key Laboratory of In\u2010Fiber Integrated Optics of Ministry of Education College of Physics and Optoelectronic Engineering Harbin Engineering University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Bian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P. R. 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