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However, almost all commercialized plugs are fixed in a certain design and associated with many complications, such as spontaneous plug extrusion, epiphora, and granuloma and cannot be traced in the long\u2010term. Herein, a simple in situ forming hydrogel is developed as a tracer and degradable lacrimal plug to achieve the best match with the irregular lacrimal passages. In this strategy, methacrylate\u2010modified silk fibroin (SFMA) is served as a network, and a self\u2010assembled indocyanine green fluorescence tracer nanoparticle (FTN) is embedded as an indicator to develop the hydrogel plug using visible photo\u2010crosslinking. This SFMA\/FTN hydrogel plug has excellent biocompatibility and biodegradability, which can be noninvasively monitored by near\u2010infrared light. In vivo tests based on dry eye rabbits show that the SFMA\/FTN hydrogel plug can completely block the lacrimal passages and greatly improve the various clinical indicators of dry eye. These results demonstrate that the SFMA\/FTN hydrogel is suitable as an injectable and degradable lacrimal plug with a long\u2010term tracking function. The work offers a new approach to the development of absorbable plugs for the treatment of dry eye.<\/jats:p>","DOI":"10.1002\/adhm.202200678","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T09:39:29Z","timestamp":1657964369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["In Situ Forming Hydrogel as a Tracer and Degradable Lacrimal Plug for Dry Eye Treatment"],"prefix":"10.1002","volume":"11","author":[{"given":"Mali","family":"Dai","sequence":"first","affiliation":[{"name":"Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical University  Wenzhou Zhejiang 325001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejia","family":"Xu","sequence":"additional","affiliation":[{"name":"Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical University  Wenzhou Zhejiang 325001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Decheng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical University  Wenzhou Zhejiang 325001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical University  Wenzhou Zhejiang 325001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinxiang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical University  Wenzhou Zhejiang 325001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4351-4872","authenticated-orcid":false,"given":"Jianliang","family":"Shen","sequence":"additional","affiliation":[{"name":"Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical University  Wenzhou Zhejiang 325001 China"},{"name":"Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang 325001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Qian","sequence":"additional","affiliation":[{"name":"Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang 325001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical University  Wenzhou Zhejiang 325001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.003"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181f7f363"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.006"},{"key":"e_1_2_8_4_1","first-page":"CD006775","volume":"6","author":"Ervin A.\u2010M.","year":"2017","journal-title":"Cochrane Database Syst. 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