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Compression therapies commonly involve the use of passive bandages that suffer from issues associated with incorrect application, and although automated solutions have begun to appear; these are often bulky and hinder mobility. Emerging microtechnologies and new materials enable the development of \u201csmart\u201d compression therapy devices, which are defined as systems that use miniaturized and lightweight actuators and electronics to control the applied pressure. This paper reviews the state of the art in smart compression therapy research. A total of seventeen different devices has been identified, categorized as using one of three actuation mechanisms: pneumatic compression, motor\u2010driven mechanisms, and smart materials (including shape memory alloys, shape memory polymers, and electroactive polymers). The field is still in its relative infancy and further refinements are required to create mass manufacturable compression dressing systems that meet medical, ergonomic, and economic standards. The use of miniaturized actuators has immense potential for the development of smart compression dressings, which will ultimately lead to higher compliance, increased patient comfort, enhanced mobility, and better treatment outcomes.<\/jats:p>","DOI":"10.1002\/adhm.202200710","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T02:49:04Z","timestamp":1655952544000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Smart Compression Therapy Devices for Treatment of Venous Leg Ulcers: A Review"],"prefix":"10.1002","volume":"11","author":[{"given":"Gustavo","family":"Coelho Rezende","sequence":"first","affiliation":[{"name":"Tyndall National Institute University College Cork  Cork T12 R5CP Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5522-2597","authenticated-orcid":false,"given":"Brendan","family":"O'Flynn","sequence":"additional","affiliation":[{"name":"Tyndall National Institute University College Cork  Cork T12 R5CP Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4018-103X","authenticated-orcid":false,"given":"Conor","family":"O'Mahony","sequence":"additional","affiliation":[{"name":"Tyndall National Institute University College Cork  Cork T12 R5CP Ireland"},{"name":"SWaT Research Network Member RCSI University of Medicine and Health Sciences  Dublin D02 YN77 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/413604"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005230070021"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.293.6541.224"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13091"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331970005100101"},{"key":"e_1_2_7_6_1","unstructured":"https:\/\/www.sigvaris.com\/en\u2010ch\/expertise\/basics\/chronic\u2010venous\u2010disorders (accessed: March 2022)."},{"key":"e_1_2_7_7_1","unstructured":"https:\/\/www.sigvaris.com\/en\u2010ch\/expertise\/condition\/varicose\u2010veins (accessed: March 2022)."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009283"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12387"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13851"},{"key":"e_1_2_7_11_1","first-page":"CD002303","volume":"9","author":"Nelson E. 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