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Wound dressings with anti\u2010inflammatory and reactive oxygen species (ROS)\u2010scavenging properties are desirable for diabetic wound treatment. In this study, a shape\u2010adaptable, biodegradable, biocompatible, antioxidant, and immunomodulatory interleukin\u201033 (IL\u201033)\u2010cytogel is developed by encapsulating IL\u201033\u00a0into physically cross\u2010linked DNA hydrogels and used as wound dressings to promote diabetic wound healing. The porous microstructures and biodegradable properties of the IL\u201033\u2010cytogel ensure the local sustained\u2010release of IL\u201033 in the wound area, where the sustained\u2010release of IL\u201033 is maintained for at least 7 days. IL\u201033\u2010cytogel can induce local accumulation of group 2 innate lymphoid cells (ILC2s) and regulatory T cells (Tregs), as well as M1\u2010to\u2010M2 transition at the wound sites. Additionally, the antioxidant and biocompatible characteristics of DNA hydrogels promote the\u00a0scavenging\u00a0of\u00a0intracellular ROS\u00a0without affecting cell viability. As a result, local inflammation in the diabetic wound area is resolved upon IL\u201033\u2010cytogel treatment, which is accompanied by improved granulation tissue regeneration and accelerated wound closure. This study demonstrates a promising strategy in tissue engineering and regenerative medicine by incorporating DNA hydrogels and cytokine immunotherapy for promoting diabetic wound healing.<\/jats:p>","DOI":"10.1002\/adhm.202200782","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T01:21:52Z","timestamp":1663118512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Biodegradable and Antioxidant DNA Hydrogel as a Cytokine Delivery System for Diabetic Wound Healing"],"prefix":"10.1002","volume":"11","author":[{"given":"Zhenghao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Center for Diabetes and Metabolism Research West China Hospital Sichuan University  Chengdu 610041 China"},{"name":"The Rolf Luft Research Center for Diabetes and Endocrinology Karolinska Institutet  Stockholm SE\u201017176 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