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However, unexpected foreign body reactions (FBRs) after surgery are reported in 90% of CI recipients, resulting in the formation of fibrosis in the cochlea and progressive residual hearing loss. Zwitterion modification is universally used to reduce bio\u2010fouling and suppress FBRs but never for CI. In the present study, a zwitterionic coating is developed, which is composed of poly sulfobetaine methacrylate (PSB) and polydopamine (PDA) for cochlear implants. The PSB\u2010PDA coating shows a series of characters for an ideal anti\u2010FBRs material, including super\u2010hydrophilicity, low protein and cell adsorption, long\u2010term stability, and high biocompatibility. Compared to the uncoated controls, PSB\u2010PDA coating inhibits the activation of macrophages and reduces the release of inflammatory factors (TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20101<jats:italic>\u03b2<\/jats:italic>, NO) and fibrosis\u2010related factors (TGF\u2010<jats:italic>\u03b2<\/jats:italic>1, <jats:italic>\u03b1<\/jats:italic>\u2010SMA, collagen I). PSB\u2010PDA coated electrode arrays suppress fibrosis completely and preserve residual hearing significantly in rat CI models. These results suggest that PSB\u2010PDA coating is a novel strategy for anti\u2010fibrosis to improve the outcomes of CI.<\/jats:p>","DOI":"10.1002\/adhm.202200807","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T03:19:38Z","timestamp":1664507978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Zwitterionic Polymer\/Polydopamine Coating of Electrode Arrays Reduces Fibrosis and Residual Hearing Loss after Cochlear Implantation"],"prefix":"10.1002","volume":"12","author":[{"given":"Anning","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery, Zhujiang Hospital Southern Medical University  Guangzhou 510282 China"},{"name":"Hearing Research Center Southern Medical University  Guangzhou 510282 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxiu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery, Zhujiang Hospital Southern Medical University  Guangzhou 510282 China"},{"name":"Hearing Research Center Southern Medical University  Guangzhou 510282 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Lv","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Engineering and Technological Research Center for Drug Carrier Development Key Laboratory of Biomaterials of Guangdong Higher Education Institutes Department of Biomedical Engineering Jinan University  Guangzhou 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET\/CT\u2010MRI Center the First Affiliated Hospital of Jinan University  Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery, Zhujiang Hospital Southern Medical University  Guangzhou 510282 China"},{"name":"Hearing Research Center Southern Medical University  Guangzhou 510282 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1814-7348","authenticated-orcid":false,"given":"Dong","family":"Ma","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Engineering and Technological Research Center for Drug Carrier Development Key Laboratory of Biomaterials of Guangdong Higher Education Institutes Department of Biomedical Engineering Jinan University  Guangzhou 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7882-4462","authenticated-orcid":false,"given":"Jie","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; 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