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A drug delivery nano\u2010controller of PD\u2010L1 that targets NSCLC\u2010SM can solve this problem, however, none have been developed to date. In this study, it is shown that integrin <jats:italic>\u03b2<\/jats:italic>3 (<jats:italic>\u03b2<\/jats:italic>3\u2010int) is strongly upregulated in NSCLC\u2010SM. Its inhibitor RGDyK promotes PD\u2010L1 ubiquitination, indicating the potential application of RGDyK as a new PD\u2010L1 inhibitor in nano\u2010controller and a targeting peptide for NSCLC\u2010SM treatment. According to the synergistic effect of photodynamic therapy and ICIs on T\u2010cell activation through the release of tumor antigens, RGDyK\u2010modified and zinc protoporphyrin (ZnPP)\u2010loaded mesoporous silicon nanoparticles (ZnPP@MSN\u2010RGDyK) are fabricated. The ZnPP@MSN\u2010RGDyK nanoparticles precisely target <jats:italic>\u03b2<\/jats:italic>3\u2010int to inhibit PD\u2010L1, exhibiting high photodynamic therapy efficiency, and excellent immunotherapeutic effects in an NSCLC\u2010SM mouse model. Collectively, the findings indicate that ZnPP@MSN\u2010RGDyK is a promising immunotherapeutic agent for treating NSCLC\u2010SM.<\/jats:p>","DOI":"10.1002\/adhm.202200938","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T10:58:52Z","timestamp":1659092332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Precisely Targeted Nano\u2010Controller of PD\u2010L1 Level for Non\u2010Small Cell Lung Cancer Spinal Metastasis Immunotherapy"],"prefix":"10.1002","volume":"11","author":[{"given":"Lei","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Zhongshan Hospital Fudan University  Shanghai 200032 P. 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