{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:58:23Z","timestamp":1780081103867,"version":"3.54.0"},"reference-count":35,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771952"],"award-info":[{"award-number":["81771952"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In\u2010stent restenosis (ISR) is seriously affecting the long\u2010term prognosis of vascular interventional therapy and leading to enormous medical burdens. Great efforts have been devoted to developing functional vascular stents with desired features and properties for effective ISR prevention. Here, a multifunctional bionic vascular stent with designed coatings prepared using microfluidic electrospinning technology is presented. Such stents are composed of biocompatible, drug\u2010loaded methylacrylated gelatin\u2010polyethylene glycol diacrylate (GelMA\u2010PEGDA) and polycaprolactone composite nanofibers on 316L stainless steel stents by an easy\u2010to\u2010operate step\u2010by\u2010step spraying method. Benefitting from the addition of polydopamine during the fabrications, the drug\u2010loaded composite nanofibers can adhere well to both the stent and the vascular wall. Furthermore, as the inner fibrous layer of the stent contacting the lumen is equipped with heparin\u2010vascular endothelial growth factor (Hep\u2010VEGF), it plays an anticoagulation role and promotes the growth of endothelial cells; while the outer layer contacts the vascular wall and releases rapamycin slowly, which can restrain smooth muscle proliferation. By implanting this into the rabbit carotid artery, the multi\u2010functional bionic demonstrates that the vascular stent can achieve good anti\u2010thrombosis and in\u2010stent restenosis effects, which indicates its potential values in vascular intervention and other biomedical fields.<\/jats:p>","DOI":"10.1002\/adhm.202200965","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T07:10:29Z","timestamp":1656573029000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Bioinspired Vascular Stents with Microfluidic Electrospun Multilayer Coatings for Preventing In\u2010Stent Restenosis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8999-2637","authenticated-orcid":false,"given":"Yi","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Affiliated Drum Tower Hospital Medical School of Nanjing University  Nanjing 210008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8790-6558","authenticated-orcid":false,"given":"Xiaoxuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4698-0924","authenticated-orcid":false,"given":"Yazhou","family":"Li","sequence":"additional","affiliation":[{"name":"Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine  Nanjing 210008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine  Nanjing 210008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Affiliated Drum Tower Hospital Medical School of Nanjing University  Nanjing 210008 China"},{"name":"Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine  Nanjing 210008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-4000","authenticated-orcid":false,"given":"Yuanjin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Affiliated Drum Tower Hospital Medical School of Nanjing University  Nanjing 210008 China"},{"name":"State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.14.4.357"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab468"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv353"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa1096"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.4376"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp476"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-355958"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202104120"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27368-4"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-086611"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwaa034"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.10.024"},{"key":"e_1_2_9_13_1","first-page":"1458090","volume":"2020","author":"Wang J.","year":"2020","journal-title":"Research"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201805452"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201800155"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2003732117"},{"key":"e_1_2_9_17_1","first-page":"9203906","volume":"2020","author":"Yang Y.","year":"2020","journal-title":"Research"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba9628"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.34133\/2019\/6175398"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2021.109101"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coco.2018.10.010"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201806899"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00309A"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201801114"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.engreg.2021.09.005"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41427-018-0064-z"},{"key":"e_1_2_9_27_1","first-page":"2603048","volume":"2020","author":"Li G.","year":"2020","journal-title":"Research"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201805460"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.7b00605"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120018"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb5067"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.04.015"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.03.032"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.5669"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.10.028"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202200965","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202200965","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202200965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T21:19:49Z","timestamp":1759785589000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202200965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,6]]},"references-count":35,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/adhm.202200965"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202200965","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,6]]},"assertion":[{"value":"2022-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2200965"}}