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However, the applications are limited due to the excessively high processing temperature and uncontrollably tedious modification routes. Here, an amorphous polyaryletherketone with carboxyl groups (PAEK\u2010COOH) is synthesized and fabricated to the hierarchically controllable porous scaffolds via a low\u2010temperature 3D\u2010printing process. The prepared PAEK\u2010COOH scaffolds present controllable porous structures ranging from nano\u2010 to micro\u2010scale, and their mechanical strengths are comparable to that of trabecular bone. More importantly, the in vitro experiments show that the nanoporous surface is conducive to promoting cellular adhesion, and carboxyl groups can induce hydroxyapatite mineralization via electrostatic interaction. The in vivo experiments demonstrate that the PAEK\u2010COOH scaffolds offer much better osseointegration without additional active ingredients, compared to that of PEEK. Therefore, this work will not only develop a promising candidate for bone tissue engineering, but provide a viable method to design PAEK biomaterials.<\/jats:p>","DOI":"10.1002\/adhm.202200977","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T17:34:30Z","timestamp":1657560870000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Low\u2010Temperature Printed Hierarchically Porous Induced\u2010Biomineralization Polyaryletherketone Scaffold for Bone Tissue Engineering"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1933-2254","authenticated-orcid":false,"given":"Xinshuai","family":"Gao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P. R. China"},{"name":"University of Science and Technology of China  Hefei 230026 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghua","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Energy Materials (DNL22) Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian 116023 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifang","family":"Luan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P. R. China"},{"name":"University of Science and Technology of China  Hefei 230026 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Energy Materials (DNL22) Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian 116023 P. R. 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