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Herein, a pseudocatalytic hydrogel (AM\u2010I@Agar) with intrinsic antibacterial and photothermal activities, synthesized by incorporating prefabricated amylose\u2010iodine nanoparticles into low\u2010melting\u2010point agarose hydrogel, is explored as a bioactive agent for local treatment of subcutaneous abscesses and breast tumors. The AM\u2010I@Agar hydrogel depicts the ability of pseudocatalytic O<jats:sub>2<\/jats:sub> generation from H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> to alleviate hypoxia. Meanwhile, the AM\u2010I@Agar hydrogel exhibits temperature self\u2010regulation features, beneficial for avoiding thermal injury during photothermal therapy owing to thermochromic properties. Upon local injection into a subcutaneous abscess, methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> is effectively eliminated by the AM\u2010I@Agar hydrogel, and complete skin recovery is achieved in 8 d, demonstrating much better antibacterial effects compared with penicillin, a small\u2010molecule antibiotic. AM\u2010I\/5\u2010FU@Agar hydrogel, obtained after loading 5\u2010fluorouracil (5\u2010FU), significantly inhibits tumors in both normal 4T1 tumor\u2010bearing mice and MRSA\u2010infected 4T1 tumor\u2010bearing mice models via a synergistic photothermal\u2010chemo effect, and shows treatment efficiency superior to that achieved with photothermal therapy or 5\u2010FU alone. This work provides a concept for the design and development of bioactive agents for potential management of bacteria\u2010associated cancer.<\/jats:p>","DOI":"10.1002\/adhm.202201023","type":"journal-article","created":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T14:59:06Z","timestamp":1662303546000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Pseudocatalytic Hydrogels with Intrinsic Antibacterial and Photothermal Activities for Local Treatment of Subcutaneous Abscesses and Breast Tumors"],"prefix":"10.1002","volume":"11","author":[{"given":"Yan","family":"Ma","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering Research and Engineering Center of Biomedical Materials Anhui Provincial Institute of Translational Medicine Anhui Medical University  Hefei 230032 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanbin","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei 230009 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Research and Engineering Center of Biomedical Materials Anhui Provincial Institute of Translational Medicine Anhui Medical University  Hefei 230032 P. R. 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