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It is a challenge for the conventional wound dressings to achieve the desirable therapeutic efficacy due to the lack of biomimetic structural environment for rapid re\u2010epithelization. Inspired by the naturally existing chiral structures in skin, a novel amino acid\u2010based chiral hydrogel dressing is developed, consisting of left\u2010handed or right\u2010handed helical fibers self\u2010assembled by <jats:sc>l\/d<\/jats:sc>\u2013phenylalanine derivatives. Compared to the levorotatory chiral hydrogel (LH), the dextral chiral hydrogel (DH) shows the ability to enhance cell adhesion, proliferation, and migration, and strongly promotes diabetic wound healing and re\u2010epithelialization with a drug\u2010free mode. Interestingly, the dextral chiral hydrogel is able to actively increase adsorption of type I collagen and promote proliferation and migration of keratinocyte in an integrin and YAP\u2010mediated manner. This study not only provides a novel strategy for treatment of chronic wounds by utilizing dextral chiral hydrogel dressings, but also unveils the molecular mechanism for effect of dextral chiral structures on the promoted proliferation of keratinocyte.<\/jats:p>","DOI":"10.1002\/adhm.202201032","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T05:05:36Z","timestamp":1662095136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Chiral Hydrogel Accelerates Re\u2010Epithelization in Chronic Wounds via Mechanoregulation"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5576-3812","authenticated-orcid":false,"given":"Hanting","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Burns and Plastic Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 201900 China"},{"name":"Institute 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