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Therefore, it is desirable to develop a self\u2010adaptive hydrogel in response to skin temperature with shape adaptability and efficient antibacterial properties to prevent microbial invasion. Herein, a dually\u2010thermoresponsive hydrogel composed of poly(\n                    <jats:italic>N<\/jats:italic>\n                    \u2010isopropylacrylamide) (PNIPAm) and methacrylated\n                    <jats:italic>\u03ba<\/jats:italic>\n                    \u2010carrageenan (MA\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    \u2010CA) is designed with compliance at physiological temperature to realize shape adaptability for completely covering irregular wounds. Furthermore, the hydrogel with near\u2010infrared (NIR)\u2010responsive polypyrrole\u2010polydopamine nanoparticles (PPy\u2010PDA NPs) and Zn\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010derived zeolitic imidazolate framework (ZIF\u20108) can generate localized heat and gradually release Zn\n                    <jats:sup>2+<\/jats:sup>\n                    to realize safe, effective synergetic photothermal\u2013chemical bactericidal capability. In addition, the release rate of Zn\n                    <jats:sup>2+<\/jats:sup>\n                    can be accelerated by NIR\u2010induced heating, and thus a more efficient sterilization can be provided to severely infected wounds. Therefore, the proposed hydrogel would serve as a promising wound dressing for the full course of wound healing, with the abilities of perfectly covering the wound and adapting to regenerating tissue, and controllable photothermal\u2010chemical antibacterial capability to reach high bactericidal efficiency and long\u2010term release of antibacterial agents.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202201049","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T21:29:01Z","timestamp":1657574941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Dually\u2010Thermoresponsive Hydrogel with Shape Adaptability and Synergetic Bacterial Elimination in the Full Course of Wound Healing"],"prefix":"10.1002","volume":"11","author":[{"given":"Lan","family":"Feng","sequence":"first","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huitong","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute for Disaster Management and Reconstruction Sichuan University  Chengdu 610207 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2689-0251","authenticated-orcid":false,"given":"Weifeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University  Chengdu 610065 China"},{"name":"Med\u2010X Center for Materials Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4619-3499","authenticated-orcid":false,"given":"Changsheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University  Chengdu 610065 China"},{"name":"Med\u2010X Center for Materials Sichuan University  Chengdu 610065 China"},{"name":"College of Chemical Engineering Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170920161246"},{"key":"e_1_2_9_2_1","first-page":"141","volume":"88","author":"Sedlarik K. 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