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The therapeutic system is comprised of microfluidized dextran microgels encapsulating cisplatin\/superparamagnetic iron oxide nanoparticles (SPIONs)\u2010loaded trilaurin\u2010based lipid nanoparticles (LNPs). The microgel system is imparted hierarchically dual targeting via dextran and folic acid (FA) residues, leading to increases both in retention of the microgels in colon and in cellular uptake of the therapeutic LNPs by colon cancer cells while being used for oral therapeutic delivery. Encapsulation of the therapeutic LNPs into dextran microgels attained by microfluidized crosslinking reaction reduces gastrointestinal adhesion and prevents the FA\u2010modified LNPs from cellular transport by proton\u2010coupled FA transporters in small intestine during their oral delivery to colon. 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