{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:14:12Z","timestamp":1788923652127,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071394"],"award-info":[{"award-number":["32071394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771034"],"award-info":[{"award-number":["31771034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetic foot ulcer (DFU) treatment is challenged by persistent bacterial infection and hyperglycemia\u2010caused vascular dysplasia. Herein, self\u2010propelled nanomotors are designed to achieve biofilm microenvironment (BME)\u2010activated multistage release of NO for effective sterilization and subsequent angiogenesis promotion. CaO<jats:sub>2<\/jats:sub> nanoparticles (NPs) are capped with PDA layers, followed by complexation with Fe<jats:sup>2+<\/jats:sup> and surface grafting of cysteine\u2010NO to obtain Janus Ca@PDA<jats:sub>Fe<\/jats:sub>\u2010CNO NPs. In response to low pH in BME, the decomposition of CaO<jats:sub>2<\/jats:sub> cores generates O<jats:sub>2<\/jats:sub> from one side of Janus NPs to propel biofilm penetration, and the released H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> and Fe<jats:sup>2+<\/jats:sup> produce \u2022OH through Fenton reaction. The concurrent glutathione\u2010triggered release of NO can be converted into reactive nitrogen species, which exhibit significantly higher bactericidal efficacy than those with only generation of \u2022OH or NO. The slow release of NO for an extended time period promotes endothelial cell proliferation and migration. On <jats:italic>Staphylococcus aureus<\/jats:italic>\u2010infected skin wounds of diabetic mice, NP treatment eliminates bacterial infections and significantly elevates blood vessel densities, leading to full wound recovery and regeneration of arranged collagen fibers and skin accessories. Thus, the self\u2010propelling and multistage release of NO provide a feasible strategy to combat biofilm infection without using any antibiotics and accelerate angiogenesis and wound healing for DFU treatment.<\/jats:p>","DOI":"10.1002\/adhm.202201323","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T14:29:27Z","timestamp":1657981767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Self\u2010Propelling Nanomotors Integrated with Biofilm Microenvironment\u2010Activated NO Release to Accelerate Healing of Bacteria\u2010Infected Diabetic Wounds"],"prefix":"10.1002","volume":"11","author":[{"given":"Shuang","family":"Xie","sequence":"first","affiliation":[{"name":"Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University  Chengdu 610031 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University  Chengdu 610031 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Peng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University  Chengdu 610031 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University  Chengdu 610031 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiong","family":"Cao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University  Chengdu 610031 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University  Chengdu 610031 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1312-0215","authenticated-orcid":false,"given":"Xiaohong","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University  Chengdu 610031 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b09191"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b07173"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.09.035"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002794"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/VIW.20200065"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.113916"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-019-0560-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201903018"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7BM00264E"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120286"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.744868"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201701043"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b12873"},{"key":"e_1_2_8_14_1","first-page":"28975","volume":"12","author":"Cao Y.","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b00495"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110459"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00807D"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8NR03963A"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB00248H"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b22339"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c00170"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b03575"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502979102"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201804046"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aaz9519"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00309-w"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c02767"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202001783"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00864"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b11453"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b09871"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b06848"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201902118"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.122109"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC03521G"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB00857E"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB00008F"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202001747"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2021.03.005"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119636"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.7b03241"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c00269"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b05608"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.05.002"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2017-0372"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116175"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202201323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202201323","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202201323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T16:33:09Z","timestamp":1759768389000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202201323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,27]]},"references-count":46,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/adhm.202201323"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202201323","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,27]]},"assertion":[{"value":"2022-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2201323"}}