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Grafting perforated eardrum with autologous tissues in clinic can restore low\u2010frequency hearing but often leaves poor recovery of high\u2010frequency hearing. In this study, the potential of incorporating a thin multilayered graphene membrane (MGM) into the eardrum for broadband hearing recovery in rats is examined. The MGM shows good biocompatibility and biostability to promote the growth of eardrum cells in a regulated manner with little sign of tissue rejection and inflammatory response. After three weeks of implantation, the MGM is found to be encapsulated by a thin layer of newly grown tissue on both sides without a significant folded overgrowth that is often seen in natural healing. The perforation is well sealed, and broadband hearing recovery (1\u201332\u00a0kHz) is enabled and maintained for at least 2 months. Mechanical simulations show that the high elastic modulus of MGM and thin thickness of the reconstructed eardrum play a critical role in the recovery of high\u2010frequency hearing. This work demonstrates the promise of the use of MGM as a functional graft for perforated eardrum to recover hearing in the broadband frequency region and suggests a new acoustics\u2010related medical application for graphene\u2010related 2D materials.<\/jats:p>","DOI":"10.1002\/adhm.202201471","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T06:05:42Z","timestamp":1658988342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Interfacing Perforated Eardrums with Graphene\u2010Based Membranes for Broadband Hearing Recovery"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8449-9560","authenticated-orcid":false,"given":"Chunyan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai 200233 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