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Here, a biocompatible and biodegradable protein\u2010based bioadhesive patch (PBP) with high adhesion strength and low immunogenic response is reported. PBP exists as a strong adhesion for biological surfaces, which is higher than some conventional bioadhesives (i.e., polyethylene glycol and fibrin). Robust adhesion and strength are realized through the removal of interfacial water and fast formation of multiple supramolecular interactions induced by metal ions. The PBP's high biocompatibility is evaluated and immunogenic response in vitro and in vivo is neglected. The strong adhesion on soft biological tissues qualifies the PBP as biomedical glue outperforming some commercial products for applications in hemostasis performance, accelerated wound healing, and sealing of defected organs, anticipating to be useful as a tissue adhesive and sealant.<\/jats:p>","DOI":"10.1002\/adhm.202201578","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T03:09:05Z","timestamp":1668049745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Multifunctional Dual Cross\u2010Linked Bioadhesive Patch with Low Immunogenic Response and Wet Tissues Adhesion"],"prefix":"10.1002","volume":"12","author":[{"given":"Yang","family":"Tang","sequence":"first","affiliation":[{"name":"BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and Engineering Sichuan University  Chengdu Sichuan 610065 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