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Stromal parameters\u2010related heterogeneity in enhanced permeability and retention effect and physicochemical properties of the nanoformulations immensely contributes to their poor tumor extravasation. Herein, a novel tumor targeting strategy, where an intratumorally implanted micromagnet can significantly enhance accumulation of magneto\u2010plasmonic nanoparticles (NPs) at the micromagnet\u2010implanted tumor in bilateral colorectal tumor models while limiting their off\u2010target accumulation, is demonstrated. To this end, novel multimodal gold\/iron oxide NPs comprised of an array of multifunctional moieties with high therapeutic, sensing, and imaging potential are developed. It is also discovered that cancer cell targeted NPs in combination with static magnetic field can selectively induce cancer cell death. A multimodal caspase\u20103 nanosensor is also developed for real\u2010time visualization of selective induction of apoptosis in cancer cells. In addition, the photothermal killing capability of these NPs in vitro is evaluated, and their potential for enhanced photothermal ablation in tissue samples is demonstrated. Building on current uses of implantable devices for therapeutic purposes, this study envisions the proposed micromagnet\u2010assisted NPs delivery approach may be used to accelerate the clinical translation of various nanoformulations.<\/jats:p>","DOI":"10.1002\/adhm.202201585","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T08:41:40Z","timestamp":1665391300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Enhanced Tumor Accumulation of Multimodal Magneto\u2010Plasmonic Nanoparticles via an Implanted Micromagnet\u2010Assisted Delivery Strategy"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8337-9591","authenticated-orcid":false,"given":"Sajanlal R.","family":"Panikkanvalappil","sequence":"first","affiliation":[{"name":"Department of Imaging Dana\u2010Farber Cancer Institute and Harvard Medical School  Boston MA 02215 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