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Chemiluminescence resonance energy transfer (CRET) has emerged as a promising mode of PDT without external light. To date, related research has frequently used endogenous hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) and oxygen (O\n                    <jats:sub>2<\/jats:sub>\n                    ) inside the solid tumor microenvironment to trigger CRET\u2010mediated PDT. Unfortunately, this significantly restricts treatment efficacy and the development of further biomedical applications because of the limited amounts of endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and O\n                    <jats:sub>2<\/jats:sub>\n                    . Herein, a nanohybrid (mSiO\n                    <jats:sub>2<\/jats:sub>\n                    \/CaO\n                    <jats:sub>2<\/jats:sub>\n                    \/CPPO\/Ce6: mSCCC) nanoparticle (NP) is designed to achieve synergistic CRET\u2010mediated PDT and calcium (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    )\u2010overload\u2010mediated therapy. The calcium peroxide (CaO\n                    <jats:sub>2<\/jats:sub>\n                    ) formed inside mesoporous SiO\n                    <jats:sub>2<\/jats:sub>\n                    (mSC) with the inclusion of the chemiluminescent agent (CPPO) and photosensitizer (Ce6) self\u2010supplies H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , O\n                    <jats:sub>2<\/jats:sub>\n                    , and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    allowing for the subsequent treatments. The Ce6 in mSCCC NPs is excited by chemical energy in situ following the supply of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and O\n                    <jats:sub>2<\/jats:sub>\n                    to produce singlet oxygen (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ). The nanohybrid NPs are coated with stearic acid to avoid decomposition during blood circulation through contact with aqueous environment. This nanohybrid shows promising performance in the generation of\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    for external light\u2010free PDT and the release of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ions for Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010overloaded therapy against orthotopic hepatocellular carcinoma.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202201613","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T22:54:55Z","timestamp":1658789695000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Engineering H\n                    <sub>2<\/sub>\n                    O\n                    <sub>2<\/sub>\n                    and O\n                    <sub>2<\/sub>\n                    Self\u2010Supplying Nanoreactor to Conduct Synergistic Chemiexcited Photodynamic and Calcium\u2010Overloaded Therapy in Orthotopic Hepatic Tumors"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3711-0329","authenticated-orcid":false,"given":"Ying\u2010Chi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Chemistry National Cheng Kung University  Tainan 701 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ju","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Cheng Kung University  Tainan 701 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin\u2010Lai","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial Hospital  Kaohsiung 833 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