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The curled form of the PVA hydrogel is prepared by releasing internal stress in the bilayer structure. The inner diameter of the cuff electrode is set to less than 2\u00a0mm for immobilization to the vagus nerve (VN) of humans and pigs. The stability of the immobilization is examined, while the pressure applied to a nerve bundle is at a harmless level (\u2248200\u00a0Pa). Since the electrode is totally organic, MRI measurements can be conducted without image artifacts. The large electric capacitance of the PEDOT\u2010PU (\u224827 mF cm<jats:sup>\u22122<\/jats:sup>) ensures a safe stimulation of living tissues without Faradaic reactions. The practical performance of the cuff electrode for VN stimulation is demonstrated by observation of bradycardia induction in a pig.<\/jats:p>","DOI":"10.1002\/adhm.202201627","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T04:30:26Z","timestamp":1663907426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Totally Organic Hydrogel\u2010Based Self\u2010Closing Cuff Electrode for Vagus Nerve Stimulation"],"prefix":"10.1002","volume":"11","author":[{"given":"Daigo","family":"Terutsuki","sequence":"first","affiliation":[{"name":"Department of Finemechanics, Graduate School of Engineering Tohoku University  6\u20106\u201001 Aramaki Aoba, Aoba\u2010ku Sendai 980\u20138579 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Yoroizuka","sequence":"additional","affiliation":[{"name":"Department of Finemechanics, Graduate School of Engineering 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